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Iminodyn-22™

Product code: ab120461 (formerly Asc-461)

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Overview

Product name

Iminodyn-22™

Description

Potent, broad spectrum dynamin inhibitor

Biological description

Potent, broad spectrum dynamin inhibitor. (IC50 values are 450 nM and 390 nM for inhibition of dynamin I and II GTPase respectively). Binds to the GTPase domain at an allosteric site and displays uncompetitive antagonism with respect to GTP. Inhibits receptor mediated endocytosis (RME) and synaptic vesicle endocytosis (SVE) (IC50 values are 10.7 and 108 μM respectively).

Purity

> 98%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Iminodyn-22™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.

Properties

Chemical name

N,N'-(Propane-1,3-diyl)bis(7,8-dihydroxy-2-imino-2H-chromene-3-carboxamide)

Molecular Weight

480.43

Chemical structure

Chemical Structure

Molecular formula

C23H20N4O8

Solubility

Soluble in DMSO to 25 mM

PubChem identifier

0

Storage instructions

Store at +4°C (desiccating conditions). Do not freeze.

Research areas

Biochemicals >> Research Area >> Stroke >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Obesity >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Hypertension >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Heart disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Diabetes >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Cancer >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Pharmacology >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals

References for Iminodyn-22™ (ab120461)

This product has been referenced in:

See 1 publication for this product

Publishing research using ab120461? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"