The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution. Predicted molecular weight: 36 kDa.
FunctionTranslational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis.
Tissue specificityWidely expressed. Expressed at high level in brain.
Sequence similaritiesBelongs to the IMPACT family. Contains 1 RWD domain.