Overview

  • Product name
  • Description
    Mouse polyclonal to IMPACT
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified), corresponding to amino acids 1-320 of Human IMPACT

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab72444 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 36 kDa.

Target

  • Function
    Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis.
  • Tissue specificity
    Widely expressed. Expressed at high level in brain.
  • Sequence similarities
    Belongs to the IMPACT family.
    Contains 1 RWD domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • IMPACT antibody
    • Impact homolog (mouse) antibody
    • Impact homolog antibody
    • impact RWD domain protein antibody
    • IMPCT_HUMAN antibody
    • Imprinted and ancient gene protein homolog antibody
    • MGC33718 antibody
    • Protein IMPACT antibody
    • RWD domain containing 5 antibody
    • RWDD5 antibody
    see all

Images

  • Anti-IMPACT antibody (ab72444) + Rat brain

    Secondary
    HRP-conjugated goat anti-mouse IgG (H&L)

    Predicted band size : 36 kDa
  • All lanes : Anti-IMPACT antibody (ab72444)

    Lane 1 : IMPACT transfected lysate (human 293T cell line)
    Lane 2 : Non-transfected lysate


    Predicted band size : 36 kDa

References

This product has been referenced in:
  • Habibi D  et al. High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death. J Cell Physiol 225:196-205 (2010). WB ; Human . Read more (PubMed: 20648630) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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