The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 45 kDa (predicted molecular weight: 39 kDa).
RelevanceFunction: May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.
Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Disease: Chondrodysplasia with joint dislocations, GPAPP type
Similarity: Belongs to the inositol monophosphatase family.
PTM: Contains N-linked glycan resistant to endoglycosydase H.
Cellular localizationMembrane; Single-pass membrane protein