Overview

  • Product nameAnti-IMPDH1 antibody
    See all IMPDH1 primary antibodies
  • Description
    Rabbit polyclonal to IMPDH1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 83-113 of Human IMPDH1 (NP_001136045.1, NP_899066.1, NP_001096075.1).

  • Positive control
    • HL60 cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab123647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 55 kDa.

Target

  • FunctionRate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • Tissue specificityIMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • PathwayPurine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • Involvement in diseaseDefects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • Information by UniProt
  • Database links
  • Alternative names
    • IMDH1_HUMAN antibody
    • IMP (inosine monophosphate) dehydrogenase 1 antibody
    • IMP dehydrogenase 1 antibody
    • IMPD 1 antibody
    • IMPD antibody
    • IMPD1 antibody
    • IMPDH 1 antibody
    • IMPDH I antibody
    • IMPDH-I antibody
    • Impdh1 antibody
    • Inosine 5' monophosphate dehydrogenase 1 antibody
    • Inosine monophosphate dehydrogenase 1 antibody
    • Inosine-5''-monophosphate dehydrogenase 1 antibody
    • LCA11 antibody
    • RP10 antibody
    • sWSS2608 antibody
    see all

Anti-IMPDH1 antibody images

  • Anti-IMPDH1 antibody (ab123647) at 1/100 dilution + HL60 cell line lysate at 35 µg

    Predicted band size : 55 kDa

References for Anti-IMPDH1 antibody (ab123647)

ab123647 has not yet been referenced specifically in any publications.

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