Overview

  • Product name
    Importazole
  • Description
    Selective nuclear transport receptor importin-β inhibitor
  • Biological description
    Selective nuclear transport receptor importin-β inhibitor (IC50 = 25 μM). Blocks SINC localization at the nuclear envelope. Impairs release of importin-β cargo and induces defects in defects in spindle assembly during mitosis.
  • Purity
    > 99%

Properties

  • Chemical name

    N-(1-Phenylethyl)-2-(1-pyrrolidinyl)-4-quinazolinamine

  • Molecular weight
    318.42
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H22N4
  • CAS Number
    662163-81-7
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(Nc1nc(nc2ccccc12)N3CCCC3)c4ccccc4
  • Source

    Synthetic

References

This product has been referenced in:
  • Mojica SA  et al. SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors. Mol Biol Cell 26:1918-34 (2015). Read more (PubMed: 25788290) »
  • Bai L  et al. Importin ß-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts. Cell Signal 26:857-67 (2014). Read more (PubMed: 24440306) »
  • Soderholm JF  et al. Importazole, a small molecule inhibitor of the transport receptor importin-ß. ACS Chem Biol 6:700-8 (2011). Read more (PubMed: 21469738) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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