Overview

  • Product nameAnti-Importin 13 antibody
    See all Importin 13 primary antibodies
  • Description
    Rabbit polyclonal to Importin 13
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 143-280 of Human Importin 13 (AAH08194)

  • Positive control
    • A549, HeLa, HepG2 and HCT116 cells. MCF7 xenograft.

Properties

Applications

Our Abpromise guarantee covers the use of ab101374 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 108 kDa.
IHC-P 1/100 - 1/500. Suggested antigen retrieval using heat mediated 10mM Citrate buffer or Tris-EDTA buffer pH 8.

Target

  • FunctionFunctions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
  • Tissue specificityExpressed in fetal brain, heart, intestine and kidney.
  • Sequence similaritiesBelongs to the importin beta family.
    Contains 14 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Imp 13 antibody
    • Imp13 antibody
    • Importin-13 antibody
    • Importin13 antibody
    • IPO 13 antibody
    • Ipo13 antibody
    • IPO13_HUMAN antibody
    • Kap 13 antibody
    • Kap13 antibody
    • Karyopherin 13 antibody
    • Karyopherin-13 antibody
    • Karyopherin13 antibody
    • KIAA0274 antibody
    • Late gestation lung 2 antibody
    • Late gestation lung 2 protein antibody
    • Lgl2 antibody
    • Ran binding protein 13 antibody
    • Ran-binding protein 13 antibody
    • RanBP 13 antibody
    • RanBP13 antibody
    see all

Anti-Importin 13 antibody images

  • Anti-Importin 13 antibody (ab101374) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 108 kDa
  • Immunohistochemical analysis of paraffin-embedded MCF7 xenograft, using ab101374 at 1/500 dilution.

References for Anti-Importin 13 antibody (ab101374)

ab101374 has not yet been referenced specifically in any publications.

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