Overview

  • Product nameAnti-Importin 13 antibody
    See all Importin 13 primary antibodies
  • Description
    Rabbit polyclonal to Importin 13
  • Tested applicationsSuitable for: WB, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide containing a sequence corresponding to a region within amino acids 901-963 (SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL CRGLHGTDYT ADY) of Human Importin 13 (NP_055467).

  • Positive control
    • HeLa whole cell lysate; HeLa cells

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab95993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 108 kDa.
IP Use at 10-1 µg/mg of lysate.
ICC/IF 1/100 - 1/200.

Target

  • FunctionFunctions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
  • Tissue specificityExpressed in fetal brain, heart, intestine and kidney.
  • Sequence similaritiesBelongs to the importin beta family.
    Contains 14 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Imp 13 antibody
    • Imp13 antibody
    • Importin-13 antibody
    • Importin13 antibody
    • IPO 13 antibody
    • Ipo13 antibody
    • IPO13_HUMAN antibody
    • Kap 13 antibody
    • Kap13 antibody
    • Karyopherin 13 antibody
    • Karyopherin-13 antibody
    • Karyopherin13 antibody
    • KIAA0274 antibody
    • Late gestation lung 2 antibody
    • Late gestation lung 2 protein antibody
    • Lgl2 antibody
    • Ran binding protein 13 antibody
    • Ran-binding protein 13 antibody
    • RanBP 13 antibody
    • RanBP13 antibody
    see all

Anti-Importin 13 antibody images

  • Importin 13 was immunoprecipitated from 1 mg of HeLa whole cell lysate using 10 µg of ab95993. The precipitated Importin 13 was detected with ab95993 at 1/1000 dilution.
  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using ab95993 at 1/200 dilution. Lower image is merged with DNA probe.

References for Anti-Importin 13 antibody (ab95993)

ab95993 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95993.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"