Overview

  • Product name
    INCA-6
  • Description
    Potent, cell-permeable, selective calcineurin-NFAT interaction inhibitor
  • Biological description
    Potent, cell-permeable, selective calcineurin-NFAT interaction inhibitor (Kd = 800 nM). Blocks NFAT dephosphorylation, cytokine mRNA induction and nuclear import (~40 µM). Unlike CsA (ab120114) and FK506 (ab120223) INCA-6 does not indiscriminately block other calcineurin substrates. Anti-inflammatory agent. Active in vitro and in vivo.
  • Purity
    > 97%

Properties

  • Chemical name
    9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
  • Molecular weight
    284.31
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H12O2
  • CAS Number
    3519-82-2
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C2C3C4=CC=CC=C4C(C2=C1)C5=C3C(=O)C=CC5=O
  • Source

    Synthetic

References

This product has been referenced in:
  • Frischbutter S  et al. Evaluation of calcineurin/NFAT inhibitor selectivity in primary human Th cells using bar-coding and phospho-flow cytometry. Cytometry A 81:1005-11 (2012). Read more (PubMed: 22997026) »
  • Sieber M & Baumgrass R Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? Cell Commun Signal 7:25 (2009). Read more (PubMed: 19860902) »
  • Roehrl MH  et al. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A 101:7554-9 (2004). Read more (PubMed: 15131267) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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