Overview

  • Product name
  • Description
    Goat polyclonal to INCA
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Synthetic peptide:

    C-NHLTTQDSQIVLPS

    , corresponding to C terminal amino acids 97-110 of Human INCA (NP_001007233.1).

  • Positive control
    • Human kidney and lung lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab99280 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab99280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 15 kDa (predicted molecular weight: 12 kDa).

Target

  • Function
    Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 CARD domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAR17_HUMAN antibody
    • CARD 17 antibody
    • CARD17 antibody
    • Caspase 1 inhibitor antibody
    • Caspase recruitment domain containing protein 17 antibody
    • Caspase recruitment domain-containing protein 17 antibody
    • Caspase-1 inhibitor INCA antibody
    • Caspase1 inhibitor antibody
    • Inhibitory caspase recruitment domain (CARD) protein antibody
    • Inhibitory caspase recruitment domain protein antibody
    see all

Images

  • Anti-INCA antibody (ab99280) at 0.5 µg/ml + Human kidney lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 12 kDa

References

ab99280 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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