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Pathways

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Research Area
- + Addiction
- - + Cannabinoid
  - - + CB₁
    - - Agonists
      - Antagonists / inverse agonists
    - CB₂
    - GPR18
    - GPR55
    - Non-selective
    - Other
    - Transporters
  - + Glutamate
  - - + AMPA & Kainate
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      - + Group I
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        Modulators
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        Allosteric modulators
        
        Antagonists
    - + NMDA
    - - AP-2 binding site
      - + Glutamate Site
      - Agonists
        
        Antagonists
      - + Glycine Site
      - Agonists
        
        Antagonists
      - Ion Channel Site
      - + Polyamine Site
      - Agonists
        
        Antagonists
        
        Other
    - + Transporters
    - - Inhibitors
      - Modulators
  - + Nicotinic
  - - α3
    - α4β2
    - + α7
    - - Agonists
      - Antagonists
    - + General
    - - Agonists
      - Antagonists
  - + Opioids
  - - δ
    - + κ
    - - Agonists
      - Antagonists
    - General
    - ORL₁
    - + µ
    - - Agonists
      - Antagonists
- + Alzheimer's Disease
- - + Apoptosis & cell cycle
  - - Caspase
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - PDGFR
      - VEGFR
    - Other
    - p53
  - Cytoskeleton & motor proteins
  - + Glutamate
  - - + AMPA & Kainate
    - + Broad spectrum / non-selective
    - - Agonists
      - Antagonists
    - + mGlu
    - - General
      - + Group I
      - Agonists
        
        Antagonists
        
        Modulators
      - + Group I & II
      - Agonists
        
        Antagonists
      - + Group II
      - Agonists
        
        Antagonists
      - + Group III
      - Agonists
        
        Allosteric modulators
        
        Antagonists
    - + NMDA
    - - AP-2 binding site
      - + Glutamate Site
      - Agonists
        
        Antagonists
      - + Glycine Site
      - Agonists
        
        Antagonists
      - Ion Channel Site
      - + Polyamine Site
      - Agonists
        
        Antagonists
        
        Other
    - + Transporters
    - - Inhibitors
      - Modulators
  - Immunomodulators
  - + Muscarinic
  - - + M₁
    - - Agonists
      - Antagonists
    - + M₂
    - - Agonists
      - Antagonists
    - M₃
    - + Non-selective
    - - Agonists
      - Antagonists
  - + Nicotinic
  - - α3
    - α4β2
    - + α7
    - - Agonists
      - Antagonists
    - + General
    - - Agonists
      - Antagonists
  - + Nitric oxide signaling
  - - Antioxidants
    - + Donors / precursors
    - - Donors
      - Other
    - NOS
  - + Signaling
  - - Amyloidogenesis
    - + Angiogenesis
    - - Antiangiogenics
      - VEGFR
    - + Apoptosis & cell cycle
    - - Caspase
      - Cyclin-dependent kinase
      - + Growth factors
      - EGFR
        
        FGFR
        
        PDGFR
        
        VEGFR
      - Other
      - p53
    - + Ca²⁺ signaling
    - Cytoskeleton & motor proteins
    - DNA, RNA & protein synthesis
    - + Endocytosis & exocytosis
    - - Clathrin
      - Dynamin
    - Heat Shock Proteins
    - Immunomodulators
    - + Lipid signaling
    - + Signal transduction
    - - Cytokines
      - + Hedgehog signaling
      - Inhibitors
        
        Smoothened
      - + Inositol & cAMP signaling
      - Adenylyl cyclase
        
        cAMP
        
        Inositol lipids
        
        + Protein Kinase A
        
        Activators
        
        Inhibitors
      - JAK/STAT signaling
      - + MAPK
      - General
        
        JNK
        
        MKK/MEK
        
        MNK
        
        p38
        
        Raf kinase
      - NF-κB & IκB signaling
      - + Nitric oxide signaling
      - Antioxidants
        
        + Donors / precursors
        
        Donors
        
        Other
        
        NOS
      - + PI3K/Akt signaling
      - + Akt
        
        Activators
        
        Inhibitors
        
        mTOR
        
        PI3-kinase
      - Transcription factors
      - Wnt signaling
    - Stem Cells
- + Cancer
- - + Angiogenesis
  - + Apoptosis & cell cycle
  - - BCL
    - Caspase
    - Chk
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - Kit
      - PDGFR
      - Trk
      - VEGFR
    - Other
    - + p53
    - - Activators
      - Inhibitors
    - PARP
    - TIE
  - + Ca²⁺ signaling
  - + Cytoskeleton & motor proteins
  - - Actin
    - Inhibitors
    - Kinesin
    - Myosin
    - Other
    - Tubulin
  - + DNA, RNA & protein synthesis
  - + Epigenetics
  - + Extracellular matrix & cell adhesion
  - + Nuclear Receptors
  - + Signal transduction
  - - Cytokines, NF-κB & IκB signaling
    - G-Protein related
    - + Hedgehog signaling
    - + Inositol & cAMP signaling
    - + JAK/STAT
    - - JAK
      - STAT
    - + MAPK
    - - ERK
      - General
      - JNK
      - MKK/MEK
      - MNK
      - p38
      - Raf kinase
    - + Nitric oxide & oxidative stress
    - - Antioxidants
      - + Donors / precursors
      - Donors
        
        Other
      - NOS
      - Other
      - ROS
    - + PI3K/Akt signaling
    - - + Akt
      - Activators
        
        Inhibitors
      - Glycogen synthase kinase
      - mTOR
      - p21
      - PI3-kinase
      - PP1 & PP2A
    - Transcription factors
    - Wnt signaling
- + Depression
- - + Glutamate
  - - + AMPA & Kainate
    - + Broad spectrum / non-selective
    - - Agonists
      - Antagonists
    - + mGlu
    - - General
      - + Group I
      - Agonists
        
        Antagonists
        
        Modulators
      - + Group I & II
      - Agonists
        
        Antagonists
      - + Group II
      - Agonists
        
        Antagonists
      - + Group III
      - Agonists
        
        Allosteric modulators
        
        Antagonists
    - + NMDA
    - - AP-2 binding site
      - + Glutamate Site
      - Agonists
        
        Antagonists
      - + Glycine Site
      - Agonists
        
        Antagonists
      - Ion Channel Site
      - + Polyamine Site
      - Agonists
        
        Antagonists
        
        Other
    - + Transporters
    - - Inhibitors
      - Modulators
  - + Serotonin
  - - + 5-HT₁
    - - 5HT1_F
      - + 5HT_1A
      - Agonists
        
        Antagonists
      - + 5HT_1B
      - Agonists
        
        Antagonists
      - 5HT_1C
      - + 5HT_1D
      - Agonists
        
        Antagonists
    - + 5-HT₂
    - - + 5HT_2A
      - Agonists
        
        Antagonists
      - + 5HT_2B
      - Agonists
        
        Antagonists
      - 5HT_2C
      - + Non-selective
      - Agonists
        
        Antagonists
    - + 5-HT₃
    - - Agonists
      - Antagonists
    - 5-HT₄
    - 5-ht₅
    - + 5-HT₆
    - - Agonists
      - Antagonists
    - + 5-HT₇
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Transporters
- + Diabetes
- - + Apoptosis & cell cycle
  - - Caspase
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - PDGFR
      - VEGFR
    - Other
    - p53
  - + Ca²⁺ signaling
  - Cytoskeleton & motor proteins
  - Immunomodulators
  - + Nitric oxide signaling
  - - Antioxidants
    - + Donors / precursors
    - - Donors
      - Other
    - NOS
  - Other
  - + Potassium
  - - Activators
    - Blockers
  - + Signaling
  - - Amyloidogenesis
    - + Angiogenesis
    - - Antiangiogenics
      - VEGFR
    - + Apoptosis & cell cycle
    - - Caspase
      - Cyclin-dependent kinase
      - + Growth factors
      - EGFR
        
        FGFR
        
        PDGFR
        
        VEGFR
      - Other
      - p53
    - + Ca²⁺ signaling
    - Cytoskeleton & motor proteins
    - DNA, RNA & protein synthesis
    - + Endocytosis & exocytosis
    - - Clathrin
      - Dynamin
    - Heat Shock Proteins
    - Immunomodulators
    - + Lipid signaling
    - + Signal transduction
    - - Cytokines
      - + Hedgehog signaling
      - Inhibitors
        
        Smoothened
      - + Inositol & cAMP signaling
      - Adenylyl cyclase
        
        cAMP
        
        Inositol lipids
        
        + Protein Kinase A
        
        Activators
        
        Inhibitors
      - JAK/STAT signaling
      - + MAPK
      - General
        
        JNK
        
        MKK/MEK
        
        MNK
        
        p38
        
        Raf kinase
      - NF-κB & IκB signaling
      - + Nitric oxide signaling
      - Antioxidants
        
        + Donors / precursors
        
        Donors
        
        Other
        
        NOS
      - + PI3K/Akt signaling
      - + Akt
        
        Activators
        
        Inhibitors
        
        mTOR
        
        PI3-kinase
      - Transcription factors
      - Wnt signaling
    - Stem Cells
  - Sodium
  - + TRP
  - - Agonists
    - Blockers
- + Epigenetics
- - DNA Methyltransferases (DNMTs)
  - Histone Acetyltransferases (HATs)
  - Histone Deacetylases (HDAC)
  - Histone Methyltransferase
  - Other
- - Heart disease
- - + Adenosine
  - - + A₁
    - - Agonists
      - Antagonists
    - + A₂
    - - Agonists
      - Antagonists
    - A₃
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
  - + Adrenoceptors
  - - + α
    - - + α₁
      - Agonists
        
        Antagonists
      - + α₂
      - Agonists
        
        Antagonists
      - Non-selective
    - + β
    - - + β₁
      - Agonists
        
        Antagonist
      - + β₂
      - Agonists
        
        antagonist
      - β₃
      - + Non-selective
      - Agonist
        
        Agonists
        
        Antagonist
        
        Antagonist
    - Non-selective
    - Transporters
  - + Apoptosis & cell cycle
  - - Caspase
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - PDGFR
      - VEGFR
    - Other
    - p53
  - + Ca²⁺ signaling
  - - Ca_v channels
    - Ca²⁺-ATPase
    - CAM Kinase
    - Chelators
    - General
    - Ionophores, Indicators & Chelators
    - IP₃ & ryanodine receptors
    - Na⁺/Ca²⁺ exchange
  - Calcium
  - Cytoskeleton & motor proteins
  - Immunomodulators
  - + Nitric oxide signaling
  - - Antioxidants
    - + Donors / precursors
    - - Donors
      - Other
    - NOS
  - + Nuclear Receptors
  - - + Estrogen
    - - Agonists
      - Antagonists
    - Glucocorticoid
    - Mineralocorticoid
    - PPAR
    - Progesterone
    - Retinoic acid receptors
    - Retinoid X receptors
  - Other
  - + Potassium
  - - Activators
    - Blockers
  - - Signaling
  - - Amyloidogenesis
    - - Angiogenesis
    - - Antiangiogenics
      - VEGFR
    - + Apoptosis & cell cycle
    - - Caspase
      - Other
    - + Ca²⁺ signaling
    - - Ca_v channels
      - Ca²⁺-ATPase
      - Chelators
      - General
      - Ionophores
      - IP₃ & ryanodine receptors
      - Na⁺/Ca²⁺ exchange
    - Coenzymes
    - + Cytokine and NF-κB signaling
    - - Cytokines
      - NF-κB & IκB
      - Other
      - STAT
    - Cytoskeleton & motor proteins
    - DNA, RNA & protein synthesis
    - + Endocytosis & exocytosis
    - - Clathrin
      - Dynamin
    - Heat Shock Proteins
    - Hedgehog signaling
    - Immunomodulators
    - + Inositol & cAMP signaling
    - - Adenylyl cyclase
      - cAMP
      - Inositol lipids
      - + Protein Kinase A
      - Activators
        
        Inhibitors
    - + Lipid signaling
    - - Cyclooxygenase
      - HMG-CoA reductase
      - Inhibitors
      - Oxygenase
      - Phospholipase & Lipase
      - PI3-kinase
    - + Nitric Oxide
    - - Antioxidants
      - + Donors / precursors
      - Donors
        
        Other
      - NOS
    - Stem Cells
  - Sodium
  - + TRP
  - - Agonists
    - Blockers
- + Hypertension
- - + Adrenoceptors
  - - + α
    - - + α₁
      - Agonists
        
        Antagonists
      - + α₂
      - Agonists
        
        Antagonists
      - Non-selective
    - + β
    - - + β₁
      - Agonists
        
        Antagonist
      - + β₂
      - Agonists
        
        antagonist
      - β₃
      - + Non-selective
      - Agonist
        
        Agonists
        
        Antagonist
        
        Antagonist
    - Non-selective
    - Transporters
  - + Apoptosis & cell cycle
  - - Caspase
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - PDGFR
      - VEGFR
    - Other
    - p53
  - + Ca²⁺ signaling
  - - Ca_v channels
    - Ca²⁺-ATPase
    - CAM Kinase
    - Chelators
    - General
    - Ionophores, Indicators & Chelators
    - IP₃ & ryanodine receptors
    - Na⁺/Ca²⁺ exchange
  - Cytoskeleton & motor proteins
  - Immunomodulators
  - + Nitric oxide signaling
  - - Antioxidants
    - + Donors / precursors
    - - Donors
      - Other
    - NOS
  - + Nuclear Receptors
  - - + Estrogen
    - - Agonists
      - Antagonists
    - Glucocorticoid
    - Mineralocorticoid
    - PPAR
    - Progesterone
    - Retinoic acid receptors
    - Retinoid X receptors
  - Other
  - + Peptide Receptors
  - - + Angiotensin
    - - Agonists
      - Antagonists
    - AXOR
    - Bradykinin
    - CCK
    - Endothelin
    - Galanin
    - + Ghrelin
    - - Agonists
      - Antagonists
    - Glucagon
    - LHRH
    - Melanocyte Stimulating Hormone
    - Neuropeptide S
    - Neuropeptide Y
    - Orexin
    - Other
    - Oxytocin
    - PAR
    - Sensory Neuron Specific Receptor
    - Substance P
    - Tachykinins
    - Vasopressin
    - VIP
  - + Potassium
  - - Activators
    - Blockers
  - + Signaling
  - - Amyloidogenesis
    - + Angiogenesis
    - - Antiangiogenics
      - VEGFR
    - + Apoptosis & cell cycle
    - - Caspase
      - Cyclin-dependent kinase
      - + Growth factors
      - EGFR
        
        FGFR
        
        PDGFR
        
        VEGFR
      - Other
      - p53
    - + Ca²⁺ signaling
    - Cytoskeleton & motor proteins
    - DNA, RNA & protein synthesis
    - + Endocytosis & exocytosis
    - - Clathrin
      - Dynamin
    - Heat Shock Proteins
    - Immunomodulators
    - + Lipid signaling
    - + Signal transduction
    - - Cytokines
      - + Hedgehog signaling
      - Inhibitors
        
        Smoothened
      - + Inositol & cAMP signaling
      - Adenylyl cyclase
        
        cAMP
        
        Inositol lipids
        
        + Protein Kinase A
        
        Activators
        
        Inhibitors
      - JAK/STAT signaling
      - + MAPK
      - General
        
        JNK
        
        MKK/MEK
        
        MNK
        
        p38
        
        Raf kinase
      - NF-κB & IκB signaling
      - + Nitric oxide signaling
      - Antioxidants
        
        + Donors / precursors
        
        Donors
        
        Other
        
        NOS
      - + PI3K/Akt signaling
      - + Akt
        
        Activators
        
        Inhibitors
        
        mTOR
        
        PI3-kinase
      - Transcription factors
      - Wnt signaling
    - Stem Cells
  - Sodium
  - + TRP
  - - Agonists
    - Blockers
- + Obesity
- - + Apoptosis & cell cycle
  - - Caspase
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - PDGFR
      - VEGFR
    - Other
    - p53
  - + Ca²⁺ signaling
  - - Ca_v channels
    - Ca²⁺-ATPase
    - CAM Kinase
    - Chelators
    - General
    - Ionophores, Indicators & Chelators
    - IP₃ & ryanodine receptors
    - Na⁺/Ca²⁺ exchange
  - + Cannabinoid
  - - + CB₁
    - - Agonists
      - Antagonists / inverse agonists
    - CB₂
    - GPR18
    - GPR55
    - Non-selective
    - Other
    - Transporters
  - Cytoskeleton & motor proteins
  - Immunomodulators
  - + Muscarinic
  - - + M₁
    - - Agonists
      - Antagonists
    - + M₂
    - - Agonists
      - Antagonists
    - M₃
    - + Non-selective
    - - Agonists
      - Antagonists
  - + Nitric oxide signaling
  - - Antioxidants
    - + Donors / precursors
    - - Donors
      - Other
    - NOS
  - Other
  - + Peptide Receptors
  - - + Angiotensin
    - - Agonists
      - Antagonists
    - AXOR
    - Bradykinin
    - CCK
    - Endothelin
    - Galanin
    - + Ghrelin
    - - Agonists
      - Antagonists
    - Glucagon
    - LHRH
    - Melanocyte Stimulating Hormone
    - Neuropeptide S
    - Neuropeptide Y
    - Orexin
    - Other
    - Oxytocin
    - PAR
    - Sensory Neuron Specific Receptor
    - Substance P
    - Tachykinins
    - Vasopressin
    - VIP
  - + Potassium
  - - Activators
    - Blockers
  - + Serotonin
  - - + 5-HT₁
    - - 5HT1_F
      - + 5HT_1A
      - Agonists
        
        Antagonists
      - + 5HT_1B
      - Agonists
        
        Antagonists
      - 5HT_1C
      - + 5HT_1D
      - Agonists
        
        Antagonists
    - + 5-HT₂
    - - + 5HT_2A
      - Agonists
        
        Antagonists
      - + 5HT_2B
      - Agonists
        
        Antagonists
      - 5HT_2C
      - + Non-selective
      - Agonists
        
        Antagonists
    - + 5-HT₃
    - - Agonists
      - Antagonists
    - 5-HT₄
    - 5-ht₅
    - + 5-HT₆
    - - Agonists
      - Antagonists
    - + 5-HT₇
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Transporters
  - + Signaling
  - - Amyloidogenesis
    - + Angiogenesis
    - - Antiangiogenics
      - VEGFR
    - + Apoptosis & cell cycle
    - - Caspase
      - Cyclin-dependent kinase
      - + Growth factors
      - EGFR
        
        FGFR
        
        PDGFR
        
        VEGFR
      - Other
      - p53
    - + Ca²⁺ signaling
    - Cytoskeleton & motor proteins
    - DNA, RNA & protein synthesis
    - + Endocytosis & exocytosis
    - - Clathrin
      - Dynamin
    - Heat Shock Proteins
    - Immunomodulators
    - + Lipid signaling
    - + Signal transduction
    - - Cytokines
      - + Hedgehog signaling
      - Inhibitors
        
        Smoothened
      - + Inositol & cAMP signaling
      - Adenylyl cyclase
        
        cAMP
        
        Inositol lipids
        
        + Protein Kinase A
        
        Activators
        
        Inhibitors
      - JAK/STAT signaling
      - + MAPK
      - General
        
        JNK
        
        MKK/MEK
        
        MNK
        
        p38
        
        Raf kinase
      - NF-κB & IκB signaling
      - + Nitric oxide signaling
      - Antioxidants
        
        + Donors / precursors
        
        Donors
        
        Other
        
        NOS
      - + PI3K/Akt signaling
      - + Akt
        
        Activators
        
        Inhibitors
        
        mTOR
        
        PI3-kinase
      - Transcription factors
      - Wnt signaling
    - Stem Cells
  - Sodium
  - + TRP
  - - Agonists
    - Blockers
- + Pain & inflammation
- - + Apoptosis & cell cycle
  - - Caspase
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - PDGFR
      - VEGFR
    - Other
    - p53
  - + Ca²⁺ signaling
  - - Ca_v channels
    - Ca²⁺-ATPase
    - CAM Kinase
    - Chelators
    - General
    - Ionophores, Indicators & Chelators
    - IP₃ & ryanodine receptors
    - Na⁺/Ca²⁺ exchange
  - + Cannabinoid
  - - + CB₁
    - - Agonists
      - Antagonists / inverse agonists
    - CB₂
    - GPR18
    - GPR55
    - Non-selective
    - Other
    - Transporters
  - Cytoskeleton & motor proteins
  - + GABA
  - - + GABA_A
    - + GABA_B
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
    - Transporters
  - + Glutamate
  - - + AMPA & Kainate
    - + Broad spectrum / non-selective
    - - Agonists
      - Antagonists
    - + mGlu
    - - General
      - + Group I
      - Agonists
        
        Antagonists
        
        Modulators
      - + Group I & II
      - Agonists
        
        Antagonists
      - + Group II
      - Agonists
        
        Antagonists
      - + Group III
      - Agonists
        
        Allosteric modulators
        
        Antagonists
    - + NMDA
    - - AP-2 binding site
      - + Glutamate Site
      - Agonists
        
        Antagonists
      - + Glycine Site
      - Agonists
        
        Antagonists
      - Ion Channel Site
      - + Polyamine Site
      - Agonists
        
        Antagonists
        
        Other
    - + Transporters
    - - Inhibitors
      - Modulators
  - + Histamine
  - - + H₁
    - - Agonists
      - Antagonists
    - + H₂
    - - Agonists
      - Antagonists
    - + H₃
    - - Agonists
      - Antagonists
    - + H₄
    - - Agonists
      - Antagonists
    - Non-selective
  - Immunomodulators
  - + Nitric oxide signaling
  - - Antioxidants
    - + Donors / precursors
    - - Donors
      - Other
    - NOS
  - + Opioids
  - - δ
    - + κ
    - - Agonists
      - Antagonists
    - General
    - ORL₁
    - + µ
    - - Agonists
      - Antagonists
  - Other
  - + Peptide Receptors
  - - + Angiotensin
    - - Agonists
      - Antagonists
    - AXOR
    - Bradykinin
    - CCK
    - Endothelin
    - Galanin
    - + Ghrelin
    - - Agonists
      - Antagonists
    - Glucagon
    - LHRH
    - Melanocyte Stimulating Hormone
    - Neuropeptide S
    - Neuropeptide Y
    - Orexin
    - Other
    - Oxytocin
    - PAR
    - Sensory Neuron Specific Receptor
    - Substance P
    - Tachykinins
    - Vasopressin
    - VIP
  - + Potassium
  - - Activators
    - Blockers
  - + Signaling
  - - Amyloidogenesis
    - + Angiogenesis
    - - Antiangiogenics
      - VEGFR
    - + Apoptosis & cell cycle
    - - Caspase
      - Other
    - + Ca²⁺ signaling
    - - Ca_v channels
      - Ca²⁺-ATPase
      - Chelators
      - General
      - Ionophores
      - IP₃ & ryanodine receptors
      - Na⁺/Ca²⁺ exchange
    - Coenzymes
    - + Cytokine and NF-κB signaling
    - - Cytokines
      - NF-κB & IκB
      - Other
      - STAT
    - Cytoskeleton & motor proteins
    - DNA, RNA & protein synthesis
    - + Endocytosis & exocytosis
    - - Clathrin
      - Dynamin
    - Heat Shock Proteins
    - Hedgehog signaling
    - Immunomodulators
    - + Inositol & cAMP signaling
    - - Adenylyl cyclase
      - cAMP
      - Inositol lipids
      - + Protein Kinase A
      - Activators
        
        Inhibitors
    - + Lipid signaling
    - - Cyclooxygenase
      - HMG-CoA reductase
      - Inhibitors
      - Oxygenase
      - Phospholipase & Lipase
      - PI3-kinase
    - + Nitric Oxide
    - - Antioxidants
      - + Donors / precursors
      - Donors
        
        Other
      - NOS
    - Stem Cells
  - Sodium
  - + TRP
  - - Agonists
    - Blockers
- + Parkinson's Disease
- - + Adrenoceptors
  - - + α
    - - + α₁
      - Agonists
        
        Antagonists
      - + α₂
      - Agonists
        
        Antagonists
      - Non-selective
    - + β
    - - + β₁
      - Agonists
        
        Antagonist
      - + β₂
      - Agonists
        
        antagonist
      - β₃
      - + Non-selective
      - Agonist
        
        Agonists
        
        Antagonist
        
        Antagonist
    - Non-selective
    - Transporters
  - + Dopamine
  - - + D₁
    - - Agonists
      - Antagonists
    - + D₂
    - - Agonists
      - Antagonists
    - + D₃
    - - Agonists
      - Antagonists
    - + D₄
    - - Agonists
      - Antagonists
    - + D₅
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
    - Transporters
  - + Glutamate
  - - + AMPA & Kainate
    - + Broad spectrum / non-selective
    - - Agonists
      - Antagonists
    - + mGlu
    - - General
      - + Group I
      - Agonists
        
        Antagonists
        
        Modulators
      - + Group I & II
      - Agonists
        
        Antagonists
      - + Group II
      - Agonists
        
        Antagonists
      - + Group III
      - Agonists
        
        Allosteric modulators
        
        Antagonists
    - + NMDA
    - - AP-2 binding site
      - + Glutamate Site
      - Agonists
        
        Antagonists
      - + Glycine Site
      - Agonists
        
        Antagonists
      - Ion Channel Site
      - + Polyamine Site
      - Agonists
        
        Antagonists
        
        Other
    - + Transporters
    - - Inhibitors
      - Modulators
  - + Nicotinic
  - - α3
    - α4β2
    - + α7
    - - Agonists
      - Antagonists
    - + General
    - - Agonists
      - Antagonists
  - + Serotonin
  - - + 5-HT₁
    - - 5HT1_F
      - + 5HT_1A
      - Agonists
        
        Antagonists
      - + 5HT_1B
      - Agonists
        
        Antagonists
      - 5HT_1C
      - + 5HT_1D
      - Agonists
        
        Antagonists
    - + 5-HT₂
    - - + 5HT_2A
      - Agonists
        
        Antagonists
      - + 5HT_2B
      - Agonists
        
        Antagonists
      - 5HT_2C
      - + Non-selective
      - Agonists
        
        Antagonists
    - + 5-HT₃
    - - Agonists
      - Antagonists
    - 5-HT₄
    - 5-ht₅
    - + 5-HT₆
    - - Agonists
      - Antagonists
    - + 5-HT₇
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Transporters
- + Respiratory disease
- - + Adenosine
  - - + A₁
    - - Agonists
      - Antagonists
    - + A₂
    - - Agonists
      - Antagonists
    - A₃
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
  - + Adrenoceptors
  - - + α
    - - + α₁
      - Agonists
        
        Antagonists
      - + α₂
      - Agonists
        
        Antagonists
      - Non-selective
    - + β
    - - + β₁
      - Agonists
        
        Antagonist
      - + β₂
      - Agonists
        
        antagonist
      - β₃
      - + Non-selective
      - Agonist
        
        Agonists
        
        Antagonist
        
        Antagonist
    - Non-selective
    - Transporters
  - + Apoptosis & cell cycle
  - - Caspase
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - PDGFR
      - VEGFR
    - Other
    - p53
  - + Ca²⁺ signaling
  - - Ca_v channels
    - Ca²⁺-ATPase
    - CAM Kinase
    - Chelators
    - General
    - Ionophores, Indicators & Chelators
    - IP₃ & ryanodine receptors
    - Na⁺/Ca²⁺ exchange
  - Cytoskeleton & motor proteins
  - + Histamine
  - - + H₁
    - - Agonists
      - Antagonists
    - + H₂
    - - Agonists
      - Antagonists
    - + H₃
    - - Agonists
      - Antagonists
    - + H₄
    - - Agonists
      - Antagonists
    - Non-selective
  - Immunomodulators
  - + Muscarinic
  - - + M₁
    - - Agonists
      - Antagonists
    - + M₂
    - - Agonists
      - Antagonists
    - M₃
    - + Non-selective
    - - Agonists
      - Antagonists
  - + Nitric oxide signaling
  - - Antioxidants
    - + Donors / precursors
    - - Donors
      - Other
    - NOS
  - Other
  - + Peptide Receptors
  - - + Angiotensin
    - - Agonists
      - Antagonists
    - AXOR
    - Bradykinin
    - CCK
    - Endothelin
    - Galanin
    - + Ghrelin
    - - Agonists
      - Antagonists
    - Glucagon
    - LHRH
    - Melanocyte Stimulating Hormone
    - Neuropeptide S
    - Neuropeptide Y
    - Orexin
    - Other
    - Oxytocin
    - PAR
    - Sensory Neuron Specific Receptor
    - Substance P
    - Tachykinins
    - Vasopressin
    - VIP
  - + Potassium
  - - Activators
    - Blockers
  - + Signaling
  - - Amyloidogenesis
    - + Angiogenesis
    - - Antiangiogenics
      - VEGFR
    - + Apoptosis & cell cycle
    - - Caspase
      - Other
    - + Ca²⁺ signaling
    - - Ca_v channels
      - Ca²⁺-ATPase
      - Chelators
      - General
      - Ionophores
      - IP₃ & ryanodine receptors
      - Na⁺/Ca²⁺ exchange
    - Coenzymes
    - + Cytokine and NF-κB signaling
    - - Cytokines
      - NF-κB & IκB
      - Other
      - STAT
    - Cytoskeleton & motor proteins
    - DNA, RNA & protein synthesis
    - + Endocytosis & exocytosis
    - - Clathrin
      - Dynamin
    - Heat Shock Proteins
    - Hedgehog signaling
    - Immunomodulators
    - + Inositol & cAMP signaling
    - - Adenylyl cyclase
      - cAMP
      - Inositol lipids
      - + Protein Kinase A
      - Activators
        
        Inhibitors
    - + Lipid signaling
    - - Cyclooxygenase
      - HMG-CoA reductase
      - Inhibitors
      - Oxygenase
      - Phospholipase & Lipase
      - PI3-kinase
    - + Nitric Oxide
    - - Antioxidants
      - + Donors / precursors
      - Donors
        
        Other
      - NOS
    - Stem Cells
  - Sodium
  - + TRP
  - - Agonists
    - Blockers
- + Schizophrenia
- - + Adrenoceptors
  - - + α
    - - + α₁
      - Agonists
        
        Antagonists
      - + α₂
      - Agonists
        
        Antagonists
      - Non-selective
    - + β
    - - + β₁
      - Agonists
        
        Antagonist
      - + β₂
      - Agonists
        
        antagonist
      - β₃
      - + Non-selective
      - Agonist
        
        Agonists
        
        Antagonist
        
        Antagonist
    - Non-selective
    - Transporters
  - + Dopamine
  - - + D₁
    - - Agonists
      - Antagonists
    - + D₂
    - - Agonists
      - Antagonists
    - + D₃
    - - Agonists
      - Antagonists
    - + D₄
    - - Agonists
      - Antagonists
    - + D₅
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
    - Transporters
  - + GABA
  - - + GABA_A
    - + GABA_B
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
    - Transporters
  - + Glutamate
  - - + AMPA & Kainate
    - + Broad spectrum / non-selective
    - - Agonists
      - Antagonists
    - + mGlu
    - - General
      - + Group I
      - Agonists
        
        Antagonists
        
        Modulators
      - + Group I & II
      - Agonists
        
        Antagonists
      - + Group II
      - Agonists
        
        Antagonists
      - + Group III
      - Agonists
        
        Allosteric modulators
        
        Antagonists
    - + NMDA
    - - AP-2 binding site
      - + Glutamate Site
      - Agonists
        
        Antagonists
      - + Glycine Site
      - Agonists
        
        Antagonists
      - Ion Channel Site
      - + Polyamine Site
      - Agonists
        
        Antagonists
        
        Other
    - + Transporters
    - - Inhibitors
      - Modulators
  - + Muscarinic
  - - + M₁
    - - Agonists
      - Antagonists
    - + M₂
    - - Agonists
      - Antagonists
    - M₃
    - + Non-selective
    - - Agonists
      - Antagonists
  - + Nicotinic
  - - α3
    - α4β2
    - + α7
    - - Agonists
      - Antagonists
    - + General
    - - Agonists
      - Antagonists
  - + Serotonin
  - - + 5-HT₁
    - - 5HT1_F
      - + 5HT_1A
      - Agonists
        
        Antagonists
      - + 5HT_1B
      - Agonists
        
        Antagonists
      - 5HT_1C
      - + 5HT_1D
      - Agonists
        
        Antagonists
    - + 5-HT₂
    - - + 5HT_2A
      - Agonists
        
        Antagonists
      - + 5HT_2B
      - Agonists
        
        Antagonists
      - 5HT_2C
      - + Non-selective
      - Agonists
        
        Antagonists
    - + 5-HT₃
    - - Agonists
      - Antagonists
    - 5-HT₄
    - 5-ht₅
    - + 5-HT₆
    - - Agonists
      - Antagonists
    - + 5-HT₇
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Transporters
- + Stem Cells
- - Growth factors
  - Hedgehog signaling
  - JAK/STAT
  - Other
  - Wnt signaling
- + Stress / Anxiety
- - + Adrenoceptors
  - - + α
    - - + α₁
      - Agonists
        
        Antagonists
      - + α₂
      - Agonists
        
        Antagonists
      - Non-selective
    - + β
    - - + β₁
      - Agonists
        
        Antagonist
      - + β₂
      - Agonists
        
        antagonist
      - β₃
      - + Non-selective
      - Agonist
        
        Agonists
        
        Antagonist
        
        Antagonist
    - Non-selective
    - Transporters
  - + Dopamine
  - - + D₁
    - - Agonists
      - Antagonists
    - + D₂
    - - Agonists
      - Antagonists
    - + D₃
    - - Agonists
      - Antagonists
    - + D₄
    - - Agonists
      - Antagonists
    - + D₅
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
    - Transporters
  - + GABA
  - - + GABA_A
    - + GABA_B
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
    - Transporters
  - + Serotonin
  - - + 5-HT₁
    - - 5HT1_F
      - + 5HT_1A
      - Agonists
        
        Antagonists
      - + 5HT_1B
      - Agonists
        
        Antagonists
      - 5HT_1C
      - + 5HT_1D
      - Agonists
        
        Antagonists
    - + 5-HT₂
    - - + 5HT_2A
      - Agonists
        
        Antagonists
      - + 5HT_2B
      - Agonists
        
        Antagonists
      - 5HT_2C
      - + Non-selective
      - Agonists
        
        Antagonists
    - + 5-HT₃
    - - Agonists
      - Antagonists
    - 5-HT₄
    - 5-HT₅
    - + 5-HT₆
    - - Agonists
      - Antagonists
    - + 5-HT₇
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Transporters
- + Stroke
- - + Adenosine
  - - + A₁
    - - Agonists
      - Antagonists
    - + A₂
    - - Agonists
      - Antagonists
    - A₃
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
  - + Apoptosis & cell cycle
  - - Caspase
    - Cyclin-dependent kinase
    - + Growth factors
    - - EGFR
      - FGFR
      - PDGFR
      - VEGFR
    - Other
    - p53
  - + Ca²⁺ signaling
  - - Ca_v channels
    - Ca²⁺-ATPase
    - CAM Kinase
    - Chelators
    - General
    - Ionophores, Indicators & Chelators
    - IP₃ & ryanodine receptors
    - Na⁺/Ca²⁺ exchange
  - Cytoskeleton & motor proteins
  - + Glutamate
  - - + AMPA & Kainate
    - + Broad spectrum / non-selective
    - - Agonists
      - Antagonists
    - + mGlu
    - - General
      - + Group I
      - Agonists
        
        Antagonists
        
        Modulators
      - + Group I & II
      - Agonists
        
        Antagonists
      - + Group II
      - Agonists
        
        Antagonists
      - + Group III
      - Agonists
        
        Allosteric modulators
        
        Antagonists
    - + NMDA
    - - AP-2 binding site
      - + Glutamate Site
      - Agonists
        
        Antagonists
      - + Glycine Site
      - Agonists
        
        Antagonists
      - Ion Channel Site
      - + Polyamine Site
      - Agonists
        
        Antagonists
        
        Other
    - + Transporters
    - - Inhibitors
      - Modulators
  - Immunomodulators
  - + Nitric oxide signaling
  - - Antioxidants
    - + Donors / precursors
    - - Donors
      - Other
    - NOS
  - + Nuclear Receptors
  - - + Estrogen
    - - Agonists
      - Antagonists
    - Glucocorticoid
    - Mineralocorticoid
    - PPAR
    - Progesterone
    - Retinoic acid receptors
    - Retinoid X receptors
  - Other
  - + Potassium
  - - Activators
    - Blockers
  - + Signaling
  - - Amyloidogenesis
    - + Angiogenesis
    - - Antiangiogenics
      - VEGFR
    - + Apoptosis & cell cycle
    - - Caspase
      - Cyclin-dependent kinase
      - + Growth factors
      - EGFR
        
        FGFR
        
        PDGFR
        
        VEGFR
      - Other
      - p53
    - + Ca²⁺ signaling
    - Cytoskeleton & motor proteins
    - DNA, RNA & protein synthesis
    - + Endocytosis & exocytosis
    - - Clathrin
      - Dynamin
    - Heat Shock Proteins
    - Immunomodulators
    - + Lipid signaling
    - + Signal transduction
    - - Cytokines
      - + Hedgehog signaling
      - Inhibitors
        
        Smoothened
      - + Inositol & cAMP signaling
      - Adenylyl cyclase
        
        cAMP
        
        Inositol lipids
        
        + Protein Kinase A
        
        Activators
        
        Inhibitors
      - JAK/STAT signaling
      - + MAPK
      - General
        
        JNK
        
        MKK/MEK
        
        MNK
        
        p38
        
        Raf kinase
      - NF-κB & IκB signaling
      - + Nitric oxide signaling
      - Antioxidants
        
        + Donors / precursors
        
        Donors
        
        Other
        
        NOS
      - + PI3K/Akt signaling
      - + Akt
        
        Activators
        
        Inhibitors
        
        mTOR
        
        PI3-kinase
      - Transcription factors
      - Wnt signaling
    - Stem Cells
  - Sodium
  - + TRP
  - - Agonists
    - Blockers

Chemical Type

Product Range

Pharmacology
- + Enzymes
- - + ATPase & GTPase
  - - Activators
    - Inhibitors
    - Substrates
  - Carbonic anhydrase
  - Carboxylase
  - Caspase
  - Cholinesterase
  - + Coenzymes
  - - Activators
    - Inhibitors
  - + Cyclase
  - - + Adenylyl cyclase
    - - Activators
      - Inhibitors
    - + Guanylyl cyclase
    - - Inhibitors
      - Other
    - Other
  - + Cyclooxygenase
  - - Activators
    - Inhibitors
    - Substrates
  - + Cytochrome P450
  - - Inhibitors
    - Other
  - + Deacetylase
  - - + Histone Deacetylase (HDAC)
    - - General
      - HDAC1
      - HDAC2
      - HDAC6
      - Sirtuins (SIRT)
    - Other
  - Deaminase
  - Decarboxylase
  - + Dehydrogenase
  - - Activators
    - Inhibitors
  - Demethylase
  - Enkephalinase
  - Esterases
  - Hydrolase
  - Hydroxylase
  - + Isomerase
  - - General
    - Topoisomerase
  - + Kinase
  - - Adenosine kinase
    - + Akt
    - - Activators
      - Inhibitors
    - ALK
    - + AMP-kinase
    - - Activators
      - Inhibitors
      - Substrates
    - ATM
    - Aurora
    - CAM Kinase
    - Casein kinase
    - Chk
    - Cyclin-dependent kinase
    - DNA-dependent Protein Kinase
    - DYRK
    - FAK
    - General
    - Glycogen synthase kinase
    - Hexokinase
    - IKK
    - JAK
    - + MAPK
    - - ERK
      - General
      - + JNK
      - Activators
        
        Inhibitors
      - MKK/MEK
      - MNK
      - p38
      - Raf kinase
    - mTOR
    - Myosin light chain kinase
    - PAK
    - PDPK1
    - + PI3-kinase
    - - Activators
      - Inhibitors
    - PIKfyve
    - PLK
    - + Protein Kinase A
    - - Activators
      - Inhibitors
    - + Protein Kinase C
    - - Activators
      - Inhibitors
    - + Protein Kinase G
    - - Activators
      - Inhibitors
    - Rho kinase
    - RSK
    - Sphingosine kinase
    - Src
    - + Tyrosine Kinase
    - - General
      - + Protein Tyrosine Kinase
      - Abl
        
        General
        
        Inhibitors
        
        Pyk
        
        Syk
      - + Receptor Tyrosine Kinase
      - c-Met
        
        CSFR1/Fms
        
        EGFR
        
        FGFR
        
        FLT3
        
        HER2/ErbB2
        
        Insulin
        
        Kit
        
        PDGFR
        
        TIE2
        
        Trk
        
        VEGFR
  - Ligase
  - + Oxidases
  - - General
    - + MAO
    - - Activators
      - Inhibitors
    - Myeloperoxidase
    - NADPH oxidase
    - Peroxidase
    - Tyrosinase
  - Oxygenase
  - + Phosphatase
  - - Alkaline phosphatase
    - Calcineurin/PP2B
    - cdc25
    - Non-selective
    - PP1 & PP2A
    - PP2B
    - Protein tyrosine phosphatase
  - Phosphodiesterase
  - + Phospholipase & Lipase
  - - Activators
    - Inhibitors
  - + Polymerase & Transcriptase
  - - DNA polymerase
    - PARP
    - RNA polymerase
    - Transcriptase
  - + Protease
  - - Aminopeptidase
    - Angiotensin-converting enzyme
    - + Calpain
    - - Activators
      - Inhibitors
    - Cathepsin
    - DUB
    - Elastase
    - General
    - Matrix metalloprotease
    - + Proteasome
    - Thrombin
    - Urokinase
  - + Reductase
  - - Aldo-keto
    - General
    - HMG-CoA reductase
  - Secretase
  - Synthetase & synthase
  - Telomerase
  - Transaminase
  - + Transferase
  - - DNA Methyltransferase (DNMT)
    - General
    - Histone Acetyltransferase (HAT)
    - + Histone Methyltransferase (HMT)
- + Ion Channels
- - + Calcium
  - - Activators
    - Blockers
  - + Chloride
  - - Activators
    - Blockers
  - Cyclic nucleotide-gated
  - Ionophores, Indicators & Chelators
  - Other
  - + Potassium
  - - Activators
    - Blockers
  - + Sodium
  - - Activators
    - Blockers
  - + TRP
  - - Agonists
    - Blockers
    - TRP
- + Receptors & Transporters
- - + Adenosine
  - - + A₁
    - - Agonists
      - Antagonists
    - + A₂
    - - Agonists
      - Antagonists
    - A₃
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
  - + Adrenoceptors
  - - + α
    - - + α₁
      - Agonists
        
        Antagonists
      - + α₂
      - Agonists
        
        Antagonists
      - + Non-selective
      - Agonists
        
        Antagonists
    - + β
    - - + β₁
      - Agonists
        
        Antagonist
      - + β₂
      - Agonists
        
        antagonist
      - + β₃
      - Agonists
        
        Antagonist
      - + Non-selective
      - Agonist
        
        Agonists
        
        Antagonist
    - + Non-selective
    - - Agonists
      - Antagonists
    - Transporters
  - + Cannabinoid
  - - + CB₁
    - - Agonists
      - Antagonists / inverse agonists
    - + CB₂
    - - Agonists
      - Antagonists / inverse agonists
    - GPR18
    - GPR55
    - Non-selective
    - Other
    - Transporters
  - Catalytic Receptors
  - + Chemokine
  - - Agonists
    - Antagonists
    - Other
  - + Dopamine
  - - + D₁
    - - Agonists
      - Antagonists
    - + D₂
    - - Agonists
      - Antagonists
    - + D₃
    - - Agonists
      - Antagonists
    - + D₄
    - - Agonists
      - Antagonists
    - + D₅
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
    - Transporters
  - + Enzyme-Linked Receptors
  - - Receptor Serine/Threonine Kinases (RSTKs)
    - + Cytokine receptors
    - - Cytokines
      - Other
    - Integrin
    - + Receptor tyrosine kinases
    - - c-Met
      - CSFR1/Fms
      - EGFR
      - FGFR
      - FLT3
      - HER2/ErbB2
      - Insulin
      - Kit
      - PDGFR
      - TIE2
      - Trk
      - VEGFR
  - Free Fatty Acid Receptors
  - G protein-coupled estrogen
  - + GABA
  - - + GABA_A
    - + GABA_B
    - + Non-selective
    - - Agonists
      - Antagonists
    - Other
    - Transporters
  - + Glutamate
  - - + AMPA & Kainate
    - + Broad spectrum / non-selective
    - + mGlu
    - - General
      - + Group I
      - Agonists
        
        Allosteric modulators
        
        Antagonists
      - + Group I & II
      - Agonists
        
        Allosteric modulators
        
        Antagonists
        
        Antibodies
      - + Group II
      - Agonists
        
        Allosteric modulators
        
        Antagonists
        
        Antibodies
      - + Group III
      - Agonists
        
        Allosteric modulators
        
        Antagonists
    - + NMDA
    - - AP-2 binding site
      - + Glutamate Site
      - Agonists
        
        Antagonists
      - + Glycine Site
      - Agonists
        
        Antagonists
      - Ion Channel Site
      - + Polyamine Site
      - Agonists
        
        Antagonists
        
        Other
    - + Transporters
    - - Inhibitors
      - Modulators
  - + Glycine
  - - Agonists
    - Antagonists
    - Transporters
  - + Histamine
  - - + H₁
    - - Agonists
      - Antagonists
    - + H₂
    - - Agonists
      - Antagonists
    - + H₃
    - + H₄
    - - Agonists
      - Antagonists
    - Histaminergic-Related Compounds
    - Non-selective
  - + Imidazoline
  - - Agonists
    - Antagonists
  - Inositol triphosphate receptor
  - Leukotriene & Related
  - Lysophospholipid receptor
  - + Melatonin
  - - MT₁
    - + MT₂
    - - Agonists
      - Antagonists
    - MT₃
  - + Muscarinic
  - - + M₁
    - + M₂
    - - Agonists
      - Antagonists
    - + M₃
    - - Agonists
      - Antagonists
    - M₄
    - M₅
    - + Non-selective
    - - Agonists
      - Antagonists
  - + Nicotinic
  - - α3
    - α4β2
    - + α7
    - - Agonists
      - Antagonists
    - + General
    - - Agonists
      - Antagonists
  - + Nuclear Receptors
  - - Androgen receptors
    - Aryl hydrocarbon receptors
    - Constitutive androstane receptor
    - + Estrogen
    - - Agonists
      - Antagonists
    - Glucocorticoid
    - LXR-like receptors
    - Mineralocorticoid
    - PPAR
    - Pregnane receptors
    - Progesterone
    - Retinoic acid receptors
    - Retinoid X receptors
    - VDR-like receptors
  - + Opioids
  - - + δ
    - - Agonists
      - Antagonists
    - + κ
    - - Agonists
      - Antagonists
    - + General
    - - Agonists
      - Antagonists
    - ORL₁
    - + µ
    - - Agonists
      - Antagonists
  - Orphan 7-TM Receptors
  - + Peptide Receptors
  - - + Angiotensin
    - - AT₁
      - AT₂
    - Apelin
    - AXOR
    - + Bombesin
    - - Agonists
      - Other
    - Bradykinin
    - Calcitonin and Related Receptors
    - CCK
    - + CRF
    - - Agonists
      - Antagonists
    - + Endothelin
    - - Agonists
      - Antagonists
    - + Galanin
    - - Agonists
      - Antagonists
    - + Ghrelin
    - - Agonists
      - Antagonists
    - + Glucagon and Related Receptors
    - - Agonists
      - Antagonists
    - LHRH
    - Melanocortin
    - Melanocyte Stimulating Hormone
    - Motilin
    - Neuromedin
    - Neuropeptide FF/AF Receptors
    - Neuropeptide S
    - Neuropeptide Y
    - Neurotensin
    - + Orexin
    - - Agonists
      - Antagonists
    - + Other
    - - Agonists
      - Antagonists
    - Oxytocin
    - + PAR
    - - Agonists
      - Antagonists
    - Secretin receptor
    - Sensory Neuron Specific Receptor
    - Somatostatin
    - Substance P
    - + Tachykinins
    - - Agonists
      - Antagonists
    - Urotensin
    - Vasopressin
    - VIP
  - Platelet-Activating Factor (PAF)
  - Prostanoid
  - + Purinergics
  - - + P1
    - - Agonists
      - Antagonists
    - + P2
    - - Non-selective
      - + P2X
      - Agonists
        
        Antagonists
      - + P2Y
      - Agonists
        
        Antagonists
  - + Serotonin
  - - + 5-HT₁
    - - + 5-HT_1A
      - Agonists
        
        Antagonists
      - + 5-HT_1B
      - Agonists
        
        Antagonists
      - 5-HT_1C
      - + 5-HT_1D
      - Agonists
        
        Antagonists
      - 5-ht_1e
      - 5-HT_1F
    - + 5-HT₂
    - - + 5-HT_2A
      - Agonists
        
        Antagonists
      - + 5-HT_2B
      - Agonists
        
        Antagonists
      - + 5-HT_2C
      - Agonists
        
        Antagonists
      - + Non-selective
      - Agonists
        
        Antagonists
    - + 5-HT₃
    - - Agonists
      - Antagonists
    - + 5-HT₄
    - - Agonists
      - Antagonists
    - 5-HT₅
    - + 5-HT₆
    - - Agonists
      - Antagonists
    - + 5-HT₇
    - - Agonists
      - Antagonists
    - + Non-selective
    - - Agonists
      - Antagonists
    - Transporters
  - Sigma
  - Smoothened
  - Sphingosine 1-Phosphate Receptors
  - TGR5
  - Toll-like Receptors
  - + Transporters
  - - ABC transporter
    - Adrenergic
    - Cannabinoid
    - Dopamine
    - GABA
    - Glutamate
    - Glutamine
    - Glycine
    - + Ion pumps / transporter
    - Serotonin
- + Signaling
- - Amyloidogenesis
  - + Angiogenesis
  - - Antiangiogenics
    - VEGFR
  - + Apoptosis & cell cycle
  - - BCL
    - Caspase
    - Chk
    - Cyclin-dependent kinase
    - + Growth factors
    - - ALK
      - EGFR
      - FGFR
      - General
      - Kit
      - PDGFR
      - Trk
      - VEGFR
    - Other
    - + p53
    - - Activators
      - Inhibitors
    - PARP
  - + Ca²⁺ signaling
  - - Ca_v channels
    - Ca²⁺ binding protein
    - Ca²⁺-ATPase
    - CAM Kinase
    - Chelators
    - General
    - Ionophores, Indicators & Chelators
    - IP₃ & ryanodine receptors
    - Na⁺/Ca²⁺ exchange
  - + Cytoskeleton & motor proteins
  - - Actin
    - Inhibitors
    - Kinesin
    - Myosin
    - Other
    - Tubulin
  - + DNA, RNA & protein synthesis
  - - DNA & RNA synthesis
    - General
    - Polymerase and transcriptase
    - Protein synthesis
    - Topoisomerase
    - Transcription factors
  - + Endocytosis & exocytosis
  - - Clathrin
    - Dynamin
    - Other
  - + Epigenetics
  - - DNA Methyltransferases (DNMTs)
    - Histone Acetyltransferases (HATs)
    - Histone Deacetylases (HDAC)
    - Histone Methyltransferase (HMT)
    - Other
  - + Extracellular matrix & cell adhesion
  - - Cell adhesion
    - Focal adhesion kinase
    - Matrix metalloprotease
    - Rho kinase
  - Heat Shock Proteins
  - + Immunomodulators
  - - Antibacterial
    - Antifungal
    - Antiparasitic
    - Antiviral
    - Immunomodulators & Immunosuppressants
    - Other
  - + Lipid signaling
  - - Cyclooxygenase
    - Diacylgycerol kinase
    - Fatty acid amide hydrolase
    - Fatty acid synthase
    - General
    - HMG-CoA reductase
    - Inhibitors
    - Metabolism
    - Oxygenase
    - + Phospholipase & Lipase
    - - Activators
      - Inhibitors
    - PI3-kinase
    - Prostaglandins
  - + Signal transduction
  - - Cytokines, NF-κB & IκB signaling
    - G-Protein related
    - + Hedgehog signaling
    - + Inositol & cAMP signaling
    - + JAK/STAT
    - - JAK
      - + STAT
      - Activators
        
        Inhibitors
    - + MAPK
    - - + ERK
      - Activators
        
        Inhibitors
      - General
      - + JNK
      - Activators
        
        Inhibitors
      - MKK/MEK
      - MNK
      - p38
      - Raf kinase
    - + Nitric oxide & oxidative stress
    - - Antioxidants
      - + Donors / precursors
      - Donors
        
        Other
      - NOS
      - Other
      - ROS
    - Notch signaling
    - + PI3K/Akt signaling
    - - + Akt
      - Activators
        
        Inhibitors
      - Glycogen synthase kinase
      - Inhibitors
      - mTOR
      - p21
      - + PI3-kinase
      - Activators
        
        Inhibitors
      - PP1 & PP2A
    - + Wnt signaling
    - - Activators
      - Inhibitors
  - + Stem Cells
  - - Growth factors
    - Hedgehog signaling
    - JAK/STAT
    - Other
    - Wnt signaling

We have 3 products in: Biochemicals >> Research Area >> Heart disease >> Signaling >> Angiogenesis

Angiogenesis

Code

Name

Details

Image Abreview Publication

Celastrol from Celastrus scandens

Anti-inflammatory and antiproliferative agent

Purity: > 99%

Anti-inflammatory and chemotherapeutic agent

Purity: > 98%

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2-Methoxyestradiol

Potent antitumor and antiangiogenic agent

Purity: > 98%

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