Past event: Cancer Degradome symposium

Organized by Gillian Murphy, Hideaki Nagase, Dylan Edwards and Abcam.

This event has now passed - please visit our Conference calendar for future Abcam events

There has long been a connection between proteases and cancer biology, since these enzymes can endow tumour cells with the ability to invade and metastasize, or spread through the body. However, we now know that proteases are involved in a host of subtle regulatory mechanisms that determine the extracellular environment, and how cells respond to their environments, and in so doing they can control cancer cell growth and death, the formation of new blood vessels (angiogenesis) that supply the growing tumour with nutrients, and also the ability of the immune system to detect cancers. It is this set of protease genes, together with their natural inhibitors, and the proteins with which they interact, that is called the DEGRADOME. We can only now appreciate that any attempt to understand the relevance of proteases in cancer must consider the extraordinary diversity and versatility of these enzymes in different contexts.

This workshop will combine the findings of the EU Framework 6 Programme on the ‘Cancer Degradome’ with those of other colleagues in the field. The focus will be on extracellular proteinases and their status as markers and therapeutic targets in cancer. The use of novel techniques to study aspects of their in vitro and in vivo functions will be a particular focus.


Royal Institute of British Architects, London


View the full program PDF


8 - 9 October 2008


                            Start:   End:
Day 1 (8 October): 10.00 - 18:00

Day 2 (9 October): 09:00 - 16:15


Gillian Murphy, Hideaki Nagase, Dylan Edwards  and Abcam

Invited speakers

  • Alicia Arroyo (Centro Nacional de Investigaciones Cardiovasculares, Madrid)
    New approaches to the understanding of the role of MT-MMPs in angiogenesis and inflammation
  • Carl Blobel (Department of Medicine, Weill Medical College of Cornell University, New York)
    Role of ADAMs in angiogenesis and breast cancer
  • Galia Blum (Department of Pathology, Stanford School of Medicine)
    Non-invasive optical imaging of cysteine proteases activity using near infrared fluorescent activity based probes
  • Thomas H. Bugge (National Institute of Dental and Craniofacial Research, Bethesda)
    Transmembrane serine proteases and their transmembrane serine protease inhibitors. Guardians of epithelial integrity
  • Vincent Dive (Commissariat à l'Energie Atomique, Saclay)
    Selective inhibitors of MMP-12: from chemistry to therapeutic applications
  • Suzanne Eccles (Institute of Cancer Research, Sutton)
    Proteinases as therapeutic targets in cancer: challenges and opportunities
  • Yoshifumi Itoh (Kennedy Institute of Rheumatology, Imperial College London)
    Temporal and spatial regulation of MT1-MMP: impact on cell migration and tubulogenesis
  • Achim Krüger (Technical University of Munich)
    Fertilizing impact of MMP-9-dependent alterations in bone marrow homeostasis on seeding of tumor cells to the liver
  • Carlos Lopez-Otin (University Institute of Oncology, Oviedo)
    Protease genomics and the cancer degradome
  • Agnès Noël (Université de Liège)
    Insight into the contribution of MMPs in lymphangiogenesis, angiogenesis and metastatic dissemination
  • Yasunori Okada (Keio University, Tokyo)
    Modulation of the tissue microenvironment in human cancers by cancer cell-derived metalloproteinases (MMPs and ADAMs): What and how can we target in cancers?
  • Thomas Reinheckel (Albert-Ludwigs-University Freiburg)
    Genetic analysis of lysosomal protease functions in mouse models for breast and skin cancer
  • Paul Saftig (Christian-Albrechts-Universität zu Kiel)
    Insight into the (patho) physiology of ADAM protease mediated shedding events
  • Bonnie Sloane (Wayne State University, Detroit)
    Tumors in the Context of Their Microenvironment: Proteolysis as a Paradigm
  • Katarina Wolf (Nijmegen Centre for Life Sciences)
    Dynamic imaging of proteases - targets in multicellular tumor invasion


  • The status of proteinases as targets in Cancer
  • Model systems to study the role of proteinases
  • In vivo imaging
  • In vitro Biology and Imaging
  • Multifarious roles of proteinases
  • Novel translational studies
  • Cell Biology

Call for abstracts

Abstracts (oral and poster) which fit the themes outlined above are now invited

Deadline for oral abstracts:            Monday 14 July 2008

Deadline for poster abstracts:        Monday 15 September 2008

Abstract submission guidelines.PDF

Registration fees

Early bird fee:       Standard rate:

£175 full                  £225 full

£125 students         £175 students

All prices are inclusive of VAT and include access to sessions; lunch and refreshments on 8 and 9 October; attendance at the welcome reception; book of abstracts and other conference materials.

Students are categorized as those in full time education at the time of registering. Proof of student status may be requested.

Early bird deadline:Monday 14 July 2008 (standard rates apply after this time)

EACR meeting bursary!

The European Association for Cancer Research (EACR) is offering a bursary to support the attendance of a presenting delegate. Full details can be found by visiting the EACR meeting bursary webpage.

Student Group Discounts

Register 4 and get 1 free!

Discounts are available for student groups attending from the same institution: register four and the fifth can attend for free. Telephone +44 (0)1223 696000 for further information.

Group Discounts - Terms & Conditions

  • The group must register together - discounts will not be applied retrospectively
  • The promotion only applies to student registrations
  • The promotion is available at either the early bird or standard rate
  • In the event of cancellation by any part of the group, no refund will be given
  • The promotion cannot be used in conjunction with any other special offer


Ellis Salsby Ltd is the appointed agent to handle the accommodation for this event. They have negotiated preferential rates at local hotels. Delegates requiring accommodation can see the Ellis Salsby website to view and book accommodation available.

Alternatively Visit London is the official website for visitors to the City with comprehensive guides to accommodation, transport and attractions.


Abcam would like to acknowledge the support of the British Society for Matrix Biology and the European Association for Cancer Research for this meeting.

British Society for Matrix Biology European Association for Cancer Research

Terms and conditions

Delegates are advised to ensure they have adequate travel insurance to cover their attendance at the conference in case of incident, or cancellation due to circumstances beyond Abcam's control.

  • All fees payable to Abcam are non-refundable
  • Substitute delegates may be made at any time

Contact us

If you have any questions please email Abcam Events Team or call +44 (0) 1223 696000

We look forward to welcoming you to London