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Venue: | Best Western Hotel & Conference Center 5625 O'Donnell Street Baltimore, Maryland 21224-4630, USA (map) | 
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Date: | November 5, 2008 |
Time: | 9:00am to 6:00pm |
Organizers: | Dr Suresh V. Ambudkar (National Cancer Institute, NIH) and Abcam, Inc. |
Meeting Focus: | The meeting will cover multidrug resistance in cancer and ABC transporters: basic, clinical, regulation and drug-drug interaction aspects. |
Contents: | |
Confirmed speakers: | - Keynote: Dr Michael M. Gottesman (National Cancer Institute, NIH)
Current status of multidrug resistance and ABC transporters - Dr Suresh V. Ambudkar (National Cancer Institute)
Mechanism of action of multidrug resistance-linked ABC drug transporters - Dr David S. Miller (National Institute of Environmental Health Sciences, NIH)
Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier - Dr. Robert B. Innis (National Institute of Mental Health, NIH)
Positron emission tomographic imaging of drug efflux transporters - Dr Gilbert J. Burckart (U.S. Food and Drug Administration)
Drug-drug interactions and regulatory implications for membrane transporter substrates in drug development - Dr Maria R. Baer (University of Maryland Greenebaum Cancer Center)
Clinical and therapeutic implications of multidrug resistance-associated ABC drug transporters
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Additional talks from submitted abstracts: | - Dr. Wilfred Stein (National Cancer Institute, NIH)
Polymorphisms within PfMDR1 alter the substrate specificity for antimalarial drugs in Plasmodium falciparum - Ms. Maria DeRosa (Hospital for Sick Children)
Inhibition of MDR1 as possible therapy for Fabry Disease - Dr. Zhe-Sheng (Jason) Chen (St. John's University)
Tyrosine kinase inhibitors as modulators of multidrug resistance in cancer - Dr. Robert Robey (National Cancer Institute, NIH)
Novel inhibitors of ABCG2 identified by high-throughput screening analysis - Dr. Demian Park (Phylonix)
Zebrafish: A predictive model for assessing modulators of P-glycoprotein efflux - Dr. Anne-Marie Bleau (Memorial Slaon-Kettering Cancer Center)
Loss of PTEN increases ABCG2 activity in glioma tumor stem cells and contributes to the MDR phenotype - Dr. Daotai Nie (Southern Illinois University School of Medicine)
The role of PXR in cancer multidrug resistance - Dr. Tianyong Zhao (University of Kentucky)
Multidrug resistance-associated protein 1 (MRP1) localizes in junction of cultured HL1 cells and mediates doxorubicin induced stress signal transmission between cells
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Program: | Full program also available as pdf download. 8:15 | Registration | 9:00 | Welcome and introduction to scope of the meeting - Dr. Suresh Ambudkar | 9:10 | Keynote speaker: Dr. Michael Gottesman - Current status of MDR and ABC transporters | 9:45 | Dr. Suresh Ambudkar - Mechanism of action of MDR-linked ABC drug transporters | 10:20 | Dr. Robert Innis - Positron emission Tomographic imaging of drug efflux transporters | 10:55 | Coffee break | 11:15 | Dr. David Miller - Regulation of P-glycoprotein and other ABC drug transporters at the bloodbrain barrier | 11:50 | Dr. Demian Park - Zebrafish: A predictive model for assessing modulators of P-glycoprotein efflux | 12:05 | Dr. Zhe-Sheng (Jason) Chen - Tyrosine kinase inhibitors as modulators of multidrug resistance in cancer | 12:25 | Lunch break | 1:15 | Dr. Maria Baer - Polymorphisms within PfMDR1 alter the substrate specificity for antimalarial drugs in Plasmodium falciparum | 1:50 | Dr. Maria Baer - Clinical and therapeutic implications of multidrug resistance-associated ABC drug transporters | 2:25 | Ms. Maria Fabiana De Rosa - Inhibition of MDR1 as possible therapy for Fabry Disease | 2:40 | Dr. Daotai Nie - The role of PXR in cancer multidrug resistance | 3:00 | Coffee break | 3:20 | Dr. Gilbert Burckart - Drug-drug interactions and regulatory implications for membrane transporter substrates in drug development | 3:55 | Dr. Anne-Marie Bleau - Loss of PTEN increases ABCG2 activity in glioma tumor stem cells and contributes to the MDR phenotype | 4:10 | Dr. Robert Robey - Novel Inhibitors of ABCG2 identified by high-throughput screening analysis | 4:25 | Dr. Tian-Yong Zhao - Multidrug resistance-associated protein 1 (MRP1) localizes in junction of cultured HL1 cells and mediates doxorubicin induced stress signal transmission between cells | 4:40 | Reception and poster session |
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| Posters will be judged. The winner will receive up to $150 off their registration for a future Abcam conference or an antibody from the Abcam catalog. Posters must be no larger than four feet tall by eight feel wide. |
Registration: | | | | Standard | Regular | | | $160.00 | Student | | | $80.00 |
The registration fee includes lunch, coffee, reception, and abstract book. Students are categorized as those in full-time education at the time of registering. Proof of student status may be requested. If you are paying via American Express, please contact Katie via email or at 617-577-4263 since we cannot take the cards online at the moment. |
Exhibitors: | Abcam is proud to have the following companies exhibiting at the meeting. Absorption Systems Absorption Systems® is “the drug absorption company”. A preclinical ADME contract research organization, we are also developing a suite of proprietary human cell lines, CellPort Technologies™ for the definitive identification and characterization of drug-transporter interactions. These models are used in the bidirectional transport assay format the FDA requires for submission. Applied Biosystems Applied Biosystems has demonstrated its position as a technology leader and driving force in the changing dynamics of the life science marketplace. The Applied Biosystems business is focused on the following markets: basic research, commercial research (pharmaceutical and biotechnology) and standardized testing, including forensic human identification, paternity testing and food testing.
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Accommodation: | Please contact the Best Western Hotel & Conference Center to see if rooms are still available. |
Parking: | Parking at the Best Western is complimentary if you are attending the meeting. |
Sponsorship opportunities: | If you are interested in sponsoring or exhibiting at this meeting, please contact us for more information. |
Meeting flier: | Download the flier for the meeting. (Warning - large file) Feel free to print it out and distribute it at your organization. |
For more information: | Katie Sedat, Abcam Events Team Phone: 617-577-4263 |