Guide to epigenetic marks

For the first time ever, the complete and definitive guide to epigenetic marks and binding proteins is available on one card

The surface of nucleosomes (composed of an octamer of the four core Histones, H3, H4, H2A and H2B, around which 147 base pairs of DNA are wrapped) is studded with a multiplicity of modifications.  Histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited. Extra complexity comes partly from the fact that methylation at lysines or arginines may be one of three different forms: mono-, di-, or trimethyl for lysines and mono- or di- (asymmetric or symmetric) for arginines. This vast array of modifications gives enormous potential for functional responses.

For the first time ever, the complete and definitive guide to epigenetic marks and binding proteins is available on one card. The card was created by Tony Kouzarides and Andy Bannister of the Gurdon Institute in association with Abcam. This resource is designed to fold out and display your pathway of interest. Request a copy today.

View the entire card PDF(4MB) or download either H3 and H2APDFH4 and H2BPDF or binding proteins PDFto view the part you are most interested in.

 

Histone H3 and H2A

Histone_marks_H3_jan09
 

Histone H4 and H2B

Histone_marks_H4_jan09
 

Histone binding proteins

Histone_marks_binding_jan09
 

Histone modification and binding protein antibodies

 

Histone modifications

 

Histone H3

Histone H2A

Histone H4

Histone H2B

Modifiers

 

 

Binding proteins

 

Chromodomain proteins

PHD proteins

14-3-3 proteins

MBT proteins

Tudor proteins

Bromodomain proteins

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