The surface of nucleosomes (composed of an octamer of the four core Histones, H3, H4, H2A and H2B, around which 147 base pairs of DNA are wrapped) is studded with a multiplicity of modifications. Histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited. Extra complexity comes partly from the fact that methylation at lysines or arginines may be one of three different forms: mono-, di-, or trimethyl for lysines and mono- or di- (asymmetric or symmetric) for arginines. This vast array of modifications gives enormous potential for functional responses.
For the first time ever, the complete and definitive guide to epigenetic marks and binding proteins is available on one card. The card was created by Tony Kouzarides and Andy Bannister of the Gurdon Institute in association with Abcam. This resource is designed to fold out and display your pathway of interest. Request a copy today.
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Histone modification and binding protein antibodies