Cardiac lineage markers of the second heart field pathway

Our new pathway card shows representative cardiac lineage markers as well as a selection of our relevant antibodies

The heart is composed of muscle and non-muscle cell lineages. During cardiogenesis, the differentiation of progenitor cells into these multiple heart cell lineages is under tight spatial and temporal control. Within the second heart field, multipotent Isl-1+ cardiovascular progenitors (MICPs) can give rise to all three major cell lineages of the heart:  cardiomyocytes, smooth muscle cells (SMCs) and, to a limited extent, endothelial cells (ECs). MICPs in the second heart field give rise to cells in the right ventricle, outflow tract, and proximal coronary arteries. Less is known about the progenitor cells of the first heart field and their derivatives which give rise to most of the left ventricular chamber. 

Cardiac lineage pathway card





Four well-characterized cardiac lineage marker antibodies

Heavy chain cardiac Mysosin antibody (ab15)

Clonality
M
Applications
ELISA, ICC/IF, IHC-Fr, IHC-P, WB
Reactivity
Hu, Ms, Rat, Cow, Pig, Rb

View Myosin antibody (ab15)

CD31(ab76533)

Clonality
M
Applications
Flow Cyt, IHC-P, IP, WB
Reactivity
Hu

View CD31 (ab76533)

Islet 1 antibody (ab20670)

Islet_1_ab20670_100x100
Clonality
P
Applications
ICC/IF, IF, IHC-Fr,
Reactivity
Hu, Ms, Rat

View Islet 1 antibody (ab20670)

alpha smooth muscle Actin antibody (ab5694)

alpha_smooth_muscle_actin_(ab5694)_100x100
Clonality
P
Applications
ELISA, ICC/IF, IHC-FoFr, IHC-FR, IHC-P, WB
Reactivity
Hu, Ms, Rat, Chk, Cow, Pig, Rb

View alpha smooth muscle Actin antibody (ab5694)

Cardiac lineage related antibodies


Product name

Applications

Product code

beta-catenin

IHC-P, WB, ICC/IF. IHC-Fr, Dot

(ab6302)

BMP-2

WB, ELISA, Dot, IHC-Fr

(ab14933)

Brachyury / Bry antibody - Mesoderm Marker

ICC/IF, IHC-Fr, IHC-P, WB

(ab2068)

CD31

ICC/IF, IP, WB

(ab24590)

cardiac Troponin T antibody

ICC/IF, WB

(ab45932)

c-kit

IHC-P, WB, ELISA, ICC/IF 

(ab5506)

c-kit

Flow Cyt, ICC/IF, IHC-P

(ab16832)

ETS1 antibody [1G11]

IHC-P, IP, WB

(ab10936)

GATA2 antibody

IHC-P, WB

(ab22849)

GATA4 (phospho S105) antibody

EMSA, WB

(ab5245)

GATA4 antibody

ELISA, ICC/IF, WB

(ab61767)

HCN4 antibody

IHC-Fr, IHC-P, WB

(ab66501)

HCN4 antibody [SHG 1E5]

IHC-Fr, WB

(ab32675)

IRX4 antibody

ELISA, WB

(ab56032)

Islet 1 antibody

ICC, IHC (PFA fixed)

(ab26122)

MDR-1/P Glycoprotein

Flow Cyt, ICC/IF

(ab10333)

MEF2A antibody

ELISA, IHC-P, WB

(ab51153)

MEF2C (phospho S387) antibody

ELISA, WB

(ab65252)

MEF2C antibody

WB

(ab43796)

Mesp-1

WB, ELISA

(ab77013)

Nkx2.5 antibody

IHC-P, WB

(ab22611)

Sca-1 (FITC-conjugated)

Flow Cyt, IP, WB, IHC-FR, CellAct

(ab25031)

Smad-1

WB, ELISA, ICC/IF

(ab63356)

Smad-1 (phospho S456)

IHC-P, ICC/IF, ELISA

(ab63439)

smooth muscle Myosin heavy chain 2

ICC/IF, IHC-Fr, WB

(ab53219)

TGF beta 1 antibody [2Ar2]

ELISA, Flow Cyt, ICC, IHC-Fr, IHC-P, Neut, WB

(ab64715)

VE Cadherin antibody

IHC-P, WB

(ab33168)

VEGF Receptor 2 antibody - Hemangioblast Marker

Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, WB

(ab2349)

VEGF Receptor 2 antibody [KDR/EIC]

ELISA, Flow Cyt, ICC/IF, IHC-Fr

(ab9530)

Wnt1

IHC-P, WB

(ab15251)

Sign up