Fc chimeric Human expressed proteins | highly purified
Some human expressed proteins are produced as extracellular domain regions fused to the Fc region of human IgG1.
Fc fusion proteins can play a role in dimerization, in vivo half-life, receptor activation and affinity for the cognate ligand. They have an advantage over soluble receptors as many receptors are only functional in a dimeric form; the dimeric receptor Fc can then mimic the activated form and enhance its affinity for the cognate ligand.
Fc chimeric proteins contain human-specific glycosylation and are suited for studies involving human proteins and cells. They can be used to neutralize the bioactivity of their cognate ligands in vitro and in vivo. They can also be used in studies to quantify receptor-ligand affinity by surface plasmon resonance.