Maintenance of Genome Stability 2012

Start date
March 5, 2012
End date
March 8, 2012
Sheraton Nassau Beach Resort
Nassau, Bahamas

DNA repair, replication and recombination
DNA repair and genome stability
DNA damage checkpoints and the cell cycle
Genome instability, disease and aging
The DDR and chromatin.

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Invited speakers

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  • Genevieve Almouzni (CNRS Institut Curie, France)
         Chromatin assembly from nucleosome to heterochromatin: the issue of DNA damage

  • Simon Boulton (Cancer Research UK, UK)
         HELQ helicase: a tumor suppressor with Fanconi Anemia and RAD51C connections

  • Junjie Chen (University of Texas, US) 
         DNA damage signaling and DNA repair

  • Karlene Cimprich (Stanford University, US)
         Genome maintenance at the replication fork

  • Alan D'Andrea (Dana Farber Cancer Institute, US) 
         Fanconi anemia as a paradigm for DDR syndromes

  • Titia De Lange (The Rockefeller University, US) 
         How telomeres repress the DNA damage response

  • Daniel Durocher (Samuel Lunenfeld Research Institute, Canada) 
         Ubiquitin-dependent DNA damage signaling

  • Steve Elledge (Harvard Medical School, US) 
         The DNA damage response

  • Susan Gasser (Friedrich Miescher Institute, Switzerland) 
         A Chemicogenetic screen reveals a role for TORC2 in the maintenance of genome stability

  • Roger Greenberg (University of Pennsylvania, US) 
         Chromatin responses to DNA double strand breaks

  • Ian Hickson (University of Copenhagen, Denmark) 
         Role of BLM in maintenance of genome stability

  • Jan Hoeijmakers (Erasmus Medical Center, The Netherlands) 
         DNA damage and repair impact on aging in mammals

  • Maria Jasin (Memorial Sloan-Kettering Cancer Center, US) 
         Protection of stalled replication forks by the BRCA2 tumor suppressor

  • Jiri Lukas (Danish Cancer Society, Denmark) 
         Spatial and temporal reprogramming of chromatin after DNA damage and replication stress

  • Andre Nussenzweig (National Cancer Institute, US) 
         Interplay between DNA double strand break repair pathways

  • Tanya Paull (University of Texas, US) 
         Functional Regulation of the Sae2/CtIP protein in DSB repair

  • Steve West (Cancer Research UK, UK) 
         Mechanisms for Holliday junction processing in DNA repair

  • Michael Yaffe (Massachusetts Institute of Technology, US) 
         A systems approach to signaling in DNA damage and genomic stability
  • Selected abstract speakers

  • Luis Aragón (MRC Clinical Sciences Centre, UK)
         SUMOylation of cohesin a-kleisin is required for damage-induced cohesion and proteolytic cleavage for 5’ to 3’ DSB end resection

  • Jiri Bartek (Danish Cancer Society, Denmark)
         Replication stress and DNA damage response in cancer development and treatment

  • Simon Bekker-Jensen (University of Copenhagen, Denmark)
         DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

  • Eric Brown (University of Pennsylvania, US)
         Regulation of irreversible fork collapse in ATR-deficient cells

  • David Cortez (Vanderbilt University School of Medicine, US)
         SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

  • James Haber (Brandeis University, US)
         Break-induced recombination and genome copy number variation

  • Susan Lees-Miller (University of Calgary, Canada)
         Potential application of PARP inhibitors in ATM- and p53 deficient malignancies

  • Markus Löbrich (Darmstadt University of Technology, Germany)
         Chromosomal translocations arising from resected DNA double-strand breaks in G1 phase

  • Noel Lowndes (National University of Ireland Galway, Ireland)
         Comparative proteomic analyses of ATM and 53BP1

  • Cynthia McMurray (Lawrence Berkeley National Laboratory, US)
         RAD50 open-closed transitions switch MRE11 from an exoonuclease to an endnuclease

  • Joanna Morris (University of Birmingham, UK)
         The proteasomal de-ubiquitinating enzyme POH1 promotes responses to double-strand breaks

  • Mark O’Connor (AstraZeneca, UK)
         Development of the PARP inhibitor olaparib to generate new therapies for cancer patients

  • Eva Petermann (University of Birmingham, UK)
         Oncogene-induced replication stress by increased initiation and conflicts with transcription

  • Brendan Price (Dana Farber Cancer Institute, US)
         Exchange of the histone variant H2A.Z onto the chromatin at DSBs by the p400 motor ATPase regulates end resection by CtIP and loading of the Ku70/80 complex

  • Rodney Rothstein (Columbia University, US)
         Increased chromosome mobility: a model for chromosome dynamics during recombination

  • Alessandro Sartori (University of Zurich, Switzerland)
         Phosphorylation-dependent isomerization of CtIP by PIN1 restrains DNA end resection

  • Ralph Scully (Beth Israel Deaconess Medical Center, US)
         BRCA1 regulates copying mechanism “choice” in sister chromatid recombination

  • Evi Soutoglou (IGBMC, France)
         DNAPKcs-dependent arrest of RNA Pol II transcription in the presence of DNA breaks

  • Manuel Stucki (University Hospital Zurich, Switzerland)
         The molecular basis for ATM-dependent MDC1 dimerization

  • Madalena Tarsounas (University of Oxford, UK)
         Replication stress and senescence in BRCA2-/- cells

  • Zhongsheng You (Washington University School of Medicine, US)
         PCNA promotes Exo1-mediated DNA end resection

  • Shan Zha (Columbia University, US)
         53BP1 and XLF have overlapping functions in end joining, lymphocyte development and cancer