Inflammation and Atherosclerosis

Start date

September 20, 2012

End date

September 21, 2012

Venue

Ludwig Maximilians University (LMU)

Location

Munich, Germany

Topics

- Genes, lipids and systemic inflammation
- Early inflammatory and immune-driven atherogenesis
- Mechanisms of progression: microRNAs, lipid and immune stress
- Novel treatment options

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Invited speakers

• Christoph Binder (Medical University of Vienna, Austria)
   Oxidation-specific epitopes are major targets of innate immunity in atherosclerosis

• Myron Cybulsky (University of Toronto, Canada)
   Arterial intimal dendritic cells and the initiation of atherosclerosis

• Stefanie Dimmeler (Goethe-University Frankfurt am Main, Germany)
   miRNAs: biomarkers and mediators for cardiovascular disease

• Ebru Erbay (Bilkent University, Turkey)
   Targeting lipotoxic endoplasmic reticulum stress in cardiometabolic syndrome

• Frederic Geissman (King's College London, UK)
   tbc

• Beat Imhof (University of Geneva, Switzerland)
   Novel molecules in vascular rearrangement

• Eicke Latz (University of Bonn, Germany)
   Inflammasome activation in atherosclerosis

• Ziad Mallat (University of Cambridge, UK)
   Immune regulatory pathways in atherosclerosis

• Fabrizio Montecucco (University of Geneva, Switzerland)
   Anti-chemokine treatments in atherosclerosis and acute ischemic complications

• Stephane Potteaux (Inserm, France)
   Monocyte subset trafficking controls plaque regression in mice

• Daniel Rader (University of Pennsylvania, US)
   New pathways in atherosclerosis identified through human genetics

• Katey Rayner (New York University, US)
   Micro-managing atherosclerosis: miRNAs In lipoprotein and plaque biology

• Laurent Yvan-Charvet (Columbia University, US)
   Cholesterol efflux pathways link stem cell mobilization to the innate immune system

Selected abstract speakers

• Jana Barlic-Dicen (Oklahoma Medical Research Foundation, US)
   Bone marrow endothelial progenitors augment atherosclerotic plaque regression in a mouse model of plasma lipid lowering

• Amanda Foks (Leiden University, The Netherlands)
   Interference of the CD30-CD30L pathway reduces atherosclerosis development

• Lesca Miriam Holdt (University Hospital Leipzig, Germany)
   Non-coding RNA ANRIL and mechanisms of atherosclerosis at human chromosome 9p21

• Daniel Ketelhuth (Karolinska Institute, Sweden)
   The tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) lowers plasma lipids and decreases atherosclerosis in hypercholesterolemic mice

• Xavier Loyer (Inserm, France)
   microRNA -92a is differentially expressed in oxLDL-activated endothelial cells in response to shear stress and modulate atherosclerosis development in mice

• Wim Martinet (University of Antwerp, Belgium)
   Drug-induced macrophage autophagy in atherosclerosis: for better or for worse?

• Andrew Newby (University of Bristol, UK)
   Foam cell macrophage polarization and MMP expression in the absence of T and B lymphocytes

• Oscar Pello (CNIC, Spain)
   Macrophage c-Myc expression level predicts the risk of atherosclerosis and regulates disease progression

• Judith Sluimer (Maastricht University, The Netherlands)
   Reversal of murine plaque hypoxia prevents apoptosis and necrotic core expansion

• Oliver Soehnlein (Ludwig Maximilians University, Germany)
   Ambivalent roles of neutrophil-derived cathelicidin in arterial healing and atherosclerosis

• Katarina Szilagyi (University of Amsterdam, The Netherlands)
   Defective signal regulatory protein alpha (SIRPa) signaling reduces atherosclerosis in mice