Inflammation and Atherosclerosis

Start date
September 20, 2012
End date
September 21, 2012
Ludwig Maximilians University (LMU)
Munich, Germany

- Genes, lipids and systemic inflammation
- Early inflammatory and immune-driven atherogenesis
- Mechanisms of progression: microRNAs, lipid and immune stress
- Novel treatment options

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Invited speakers

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Christoph Binder (Medical University of Vienna, Austria)
   Oxidation-specific epitopes are major targets of innate immunity in atherosclerosis

Myron Cybulsky (University of Toronto, Canada)
   Arterial intimal dendritic cells and the initiation of atherosclerosis

Stefanie Dimmeler (Goethe-University Frankfurt am Main, Germany)
   miRNAs: biomarkers and mediators for cardiovascular disease

Ebru Erbay (Bilkent University, Turkey)
   Targeting lipotoxic endoplasmic reticulum stress in cardiometabolic syndrome

Frederic Geissman (King's College London, UK)

Beat Imhof (University of Geneva, Switzerland)
   Novel molecules in vascular rearrangement

Eicke Latz (University of Bonn, Germany)
   Inflammasome activation in atherosclerosis

Ziad Mallat (University of Cambridge, UK)
   Immune regulatory pathways in atherosclerosis

• Fabrizio Montecucco (University of Geneva, Switzerland)
   Anti-chemokine treatments in atherosclerosis and acute ischemic complications

• Stephane Potteaux (Inserm, France)
   Monocyte subset trafficking controls plaque regression in mice

Daniel Rader (University of Pennsylvania, US)
   New pathways in atherosclerosis identified through human genetics

• Katey Rayner (New York University, US)
   Micro-managing atherosclerosis: miRNAs In lipoprotein and plaque biology

• Laurent Yvan-Charvet (Columbia University, US)
   Cholesterol efflux pathways link stem cell mobilization to the innate immune system

Selected abstract speakers

• Jana Barlic-Dicen (Oklahoma Medical Research Foundation, US)
   Bone marrow endothelial progenitors augment atherosclerotic plaque regression in a mouse model of plasma lipid lowering

• Amanda Foks (Leiden University, The Netherlands)
   Interference of the CD30-CD30L pathway reduces atherosclerosis development

• Lesca Miriam Holdt (University Hospital Leipzig, Germany)
   Non-coding RNA ANRIL and mechanisms of atherosclerosis at human chromosome 9p21

• Daniel Ketelhuth (Karolinska Institute, Sweden)
   The tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) lowers plasma lipids and decreases atherosclerosis in hypercholesterolemic mice

• Xavier Loyer (Inserm, France)
   microRNA -92a is differentially expressed in oxLDL-activated endothelial cells in response to shear stress and modulate atherosclerosis development in mice

• Wim Martinet (University of Antwerp, Belgium)
   Drug-induced macrophage autophagy in atherosclerosis: for better or for worse?

• Andrew Newby (University of Bristol, UK)
   Foam cell macrophage polarization and MMP expression in the absence of T and B lymphocytes

• Oscar Pello (CNIC, Spain)
   Macrophage c-Myc expression level predicts the risk of atherosclerosis and regulates disease progression

• Judith Sluimer (Maastricht University, The Netherlands)
   Reversal of murine plaque hypoxia prevents apoptosis and necrotic core expansion

• Oliver Soehnlein (Ludwig Maximilians University, Germany)
   Ambivalent roles of neutrophil-derived cathelicidin in arterial healing and atherosclerosis

• Katarina Szilagyi (University of Amsterdam, The Netherlands)
   Defective signal regulatory protein alpha (SIRPa) signaling reduces atherosclerosis in mice