Overview

  • Product nameIndirubin
  • Description
    Potent cyclin-dependent kinase and GSK-3β inhibitor
  • Biological descriptionPotent cyclin-dependent kinase (CDK) and GSK-3β inhibitor (IC50 values are 5.5 μM at CDK5, 9 μM at CDK1 and 600 nM at GSK-3β). Antimitotic and antitumoral properties induces cell cycle arrest, inhibits cell proliferation AMPK, LCK and SGK. Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, an over-active process in Alzheimer disease states.
  • Purity> 98%

Properties

    References for Indirubin (ab120960)

    This product has been referenced in:
    • Procházková J  et al. Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells. Toxicology 279:146-54 (2011). Read more (PubMed: 20951181) »
    • Zhang X  et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer 129:2502-11 (2011). Read more (PubMed: 21207415) »
    • Leclerc S  et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem 276:251-60 (2001). Read more (PubMed: 11013232) »

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