Anti-Indoleamine 2, 3-dioxygenase antibody (ab106134)

Overview

  • Product name
    Anti-Indoleamine 2, 3-dioxygenase antibody
    See all Indoleamine 2, 3-dioxygenase primary antibodies
  • Description
    Rabbit polyclonal to Indoleamine 2, 3-dioxygenase
  • Specificity
    Does not bind to IDO2
  • Tested applications
    Suitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A mixture of 3 peptides derived from Rat Indoleamine 2, 3-dioxygenase: MPHSQISPAEGSRRILEEY (1-19), LFSFPGGDCDKGFFLVSLMVE (155-176), and VKPSKQKPMGGHKSEEPS (359-376), conjugated to KLH.

Properties

Applications

Our Abpromise guarantee covers the use of ab106134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50. Predicted molecular weight: 45 kDa.
IHC-P 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IHC-Fr 1/50.

Target

  • Function
    Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
  • Pathway
    Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
  • Sequence similarities
    Belongs to the indoleamine 2,3-dioxygenase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3-dioxygenase antibody
    • I23O1_HUMAN antibody
    • IDO 1 antibody
    • IDO antibody
    • IDO-1 antibody
    • IDO1 antibody
    • INDO antibody
    • indolamine 2,3 dioxygenase antibody
    • Indole 2 3 dioxygenase antibody
    • indoleamine 2 3 dioxygenase 1 antibody
    • indoleamine 2 3 dioxygenase antibody
    • Indoleamine 2,3-dioxygenase 1 antibody
    • Indoleamine pyrrole 2 3 dioxygenase antibody
    • Indoleamine-pyrrole 2 antibody
    see all

Anti-Indoleamine 2, 3-dioxygenase antibody images

  • Heat inducing epitope retrieval is used as pre-treatment.  Blocking of the endogenous peroxidase is necessary to avoid unspecific background staining. 

References for Anti-Indoleamine 2, 3-dioxygenase antibody (ab106134)

This product has been referenced in:
  • Nagy-Grócz G  et al. The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat. Front Neurol 8:278 (2017). WB ; Rat . Read more (PubMed: 28659861) »
  • Bandeira LG  et al. Exogenous Tryptophan Promotes Cutaneous Wound Healing of Chronically Stressed Mice through Inhibition of TNF-a and IDO Activation. PLoS One 10:e0128439 (2015). Mouse . Read more (PubMed: 26057238) »

See all 5 Publications for this product

Product Wall

My name is Jeremy Kasanovand I'm helping Sybille with her emails while she is out of the office.

The antibody was tested by thelab which developed this antibodyfor cross reactivity with mouse IDO in Western blot. Unfortunately we have no deta...

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Thank you for your reply.

The information the lab sent me is all we have available. There is also a reference listed on the datasheet where human and rat tissue was used:

Hill M et al. Heme oxygenase-1 inhibits rat and human breast...

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I am very pleased to hear you would like to use ab106134 in mouse and send us an image of your results.

This code will give you 1 free primary antibody before the expiration date. To redeem this offer, please submit an Abreview with the imag...

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Thank you very much for your interest in ab106134 and for your patience.

Unfortunately I have not been able to obtain any more information on the tissue tested in mouse and I do not want for you to have to continue to wait for a response. Read More

I am very pleased to hear you would like to accept our offer and test ab55305 and ab106134 in monkey. These codes will give you 1 free primary antibody per code before the expiration date. To redeem this offer, please submit an Abreview for each antibo...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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