Biological descriptionNon-selective COX inhibitor (IC50 = 230 and 630 nM for human COX-1 and COX-2, respectively). Activates PPARα and PPARγ (EC50 = 40 nM).
Chemical name1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 50 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Palomer A et al. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem45:1402-11 (2002).
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Lehmann JM et al. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem272:3406-10 (1997).
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