Anti-Influenza A Nonstructural Protein 1 antibody (ab91642)

Overview

  • Product nameAnti-Influenza A Nonstructural Protein 1 antibody
    See all Influenza A Nonstructural Protein 1 primary antibodies
  • Description
    Rabbit polyclonal to Influenza A Nonstructural Protein 1
  • SpecificitySpecific for the seasonal Influenza A Nonstructural Protein 1. Does not bind the corresponding Nonstructural Protein 1 from the swine flu Influenza A virus.
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with seasonal Influenza A H1N1 virus. Does not react with Swine flu Influenza A H1N1 virus.
  • Immunogen

    Synthetic peptide specific for the seasonal Influenza A H1N1 Nonstructural Protein 1 (ABP49398).

Properties

Applications

Our Abpromise guarantee covers the use of ab91642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
  • Application notesELISA: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceInfluenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. The virus has one of sixteen possible hemagglutinin (HA) surface proteins and one of nine possible neuraminidase (NA) surface proteins. In early 2009, a novel H1N1 swine-origin influenza (S-OIV) A virus was identified in specimens obtained from patients in Mexico and the United States. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2’-5’ OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the antiviral protein kinase PKR.
    • Cellular localizationhost cell cytoplasm and nucleus
    • Alternative names
      • Nonstructural protein 1 antibody
      • NS1 antibody
      • NS1A antibody

    References for Anti-Influenza A Nonstructural Protein 1 antibody (ab91642)

    ab91642 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"