Anti-Influenza A Virus M2 Protein antibody [14C2] - BSA and Azide free (ab96689)

Overview

  • Product nameAnti-Influenza A Virus M2 Protein antibody [14C2] - BSA and Azide free
    See all Influenza A Virus M2 Protein primary antibodies
  • Description
    Mouse monoclonal [14C2] to Influenza A Virus M2 Protein - BSA and Azide free
  • Species reactivity
    Reacts with: Influenza A
  • Immunogen

    Full length M2 protein from A/WSN/33-infected CV1 cell lysate.

  • EpitopeDetects the N-terminal of the Influenza A Virus M2 Protein.
  • General notes


    Influenza A virus is an enveloped virus encoding 10 polypeptides. RNA segment 7 encodes for two proteins: M1 (matrix 1) and M2 (matrix 2). M1 protein is encoded by an mRNA that is colinear, while M2 protein is synthesized from spliced mRNA. M2 protein is a transmembrane protein composed of three Domains: 1) 24 residues representing the N-terminal region, 2) 19 hydro-phobic residues that serve as a membrane anchor, and 3) 54 residues near the C-terminal in the cytoplasmic domain. The M2 protein has been found to play a role in Influenza replication and assembly of virion particles. Further experimentation has demonstrated that this protein is an acid-activated ion channel for virus replication.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferConstituent: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Primary antibody notesInfluenza A virus is an enveloped virus encoding 10 polypeptides. RNA segment 7 encodes for two proteins: M1 (matrix 1) and M2 (matrix 2). M1 protein is encoded by an mRNA that is colinear, while M2 protein is synthesized from spliced mRNA. M2 protein is a transmembrane protein composed of three Domains: 1) 24 residues representing the N-terminal region, 2) 19 hydro-phobic residues that serve as a membrane anchor, and 3) 54 residues near the C-terminal in the cytoplasmic domain. The M2 protein has been found to play a role in Influenza replication and assembly of virion particles. Further experimentation has demonstrated that this protein is an acid-activated ion channel for virus replication.
  • ClonalityMonoclonal
  • Clone number14C2
  • IsotypeIgG1
  • Research areas

Target

  • RelevanceThe Matrix protein M2 forms a protons channel. When the environmental pH is lower than a threshold, the M2 channel is activated and selectively transports protons accross the membrane from the extracellular side to the cytoplasmic side. It is crucial for the uncoating process. When the virion is internalized into the endosome the channel can acidify the virion interior, promoting the dissociation of the viral matrix protein (M1) from the ribonucleoprotein (RNP) thus allowing the transport of the RNP from the virion into the cell’s nucleus. For some influenza virus subtypes, the M2 channel can elevate the intravesicular pH of the trans Golgi network, preventing the viral protein haemagglutinin, which is transported to the cell surface through the trans Golgi network, from incorrect maturation in an otherwise low pH environment.
  • Cellular localizationVirion membrane. Apical cell membrane; Single-pass type III membrane protein.
  • Database links
    • Alternative names
      • Influenza A virus matrix protein M2 antibody
      • M antibody
      • M2 antibody
      • Matrix protein 2 antibody
      • Membrane ion channel M2 antibody
      • Membrane protein M2 antibody
      • Proton channel protein M2 antibody
      see all

    References for Anti-Influenza A Virus M2 Protein antibody [14C2] - BSA and Azide free (ab96689)

    ab96689 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you very much for your patience.

    Finally, I have a price quote and custom made confirmation from laboratory. We are happy to provide this product at lower cost than ab5416. The price would be £194 per vial or £582 for 3 vial...

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    I have sent a request to laboratory for quote; I will send you the details soon.

    Many thanks for having patience!

    Thank you for your email.

    I just spoken to my colleague in laboratory; they have suggested that in order to justify the production cost for making it BSA and azide free at least 3 vials should be ordered. Could you let me know if you will buy ...

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    Thank you for contacting us.

    We can provide this product, BSA and azide free as a special request. Could you let me know how many vials you would like to buy?

    Looking forward to hearing from you soon.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"