Anti-Influenza A Virus M2 Protein antibody (ab94925)
Key features and details
- Rabbit polyclonal to Influenza A Virus M2 Protein
- Suitable for: WB
- Reacts with: Influenza A
- Isotype: IgG
Overview
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Product name
Anti-Influenza A Virus M2 Protein antibody
See all Influenza A Virus M2 Protein primary antibodies -
Description
Rabbit polyclonal to Influenza A Virus M2 Protein -
Host species
Rabbit -
Specificity
ab94925 detects Influenza A Virus M2 Protein. It may crossreact with M2 protein from other strains of influenza. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Influenza A -
Immunogen
A 13 amino acid peptide from the N terminus of Influenza A Virus M2 Protein.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Affinity chromatography purified via peptide column. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab94925 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent dilution. Predicted molecular weight: 11 kDa.
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Notes |
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WB
Use at an assay dependent dilution. Predicted molecular weight: 11 kDa. |
Target
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Relevance
The Matrix protein M2 forms a protons channel. When the environmental pH is lower than a threshold, the M2 channel is activated and selectively transports protons accross the membrane from the extracellular side to the cytoplasmic side. It is crucial for the uncoating process. When the virion is internalized into the endosome the channel can acidify the virion interior, promoting the dissociation of the viral matrix protein (M1) from the ribonucleoprotein (RNP) thus allowing the transport of the RNP from the virion into the cell’s nucleus. For some influenza virus subtypes, the M2 channel can elevate the intravesicular pH of the trans Golgi network, preventing the viral protein haemagglutinin, which is transported to the cell surface through the trans Golgi network, from incorrect maturation in an otherwise low pH environment. -
Cellular localization
Virion membrane. Apical cell membrane; Single-pass type III membrane protein. -
Database links
- Entrez Gene: 1461002 Influenza A
- Entrez Gene: 956528 Influenza A
- SwissProt: A0A2R3YRM7 Influenza A
- SwissProt: P06821 Influenza A
- SwissProt: Q67179 Influenza A
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Alternative names
- Influenza A virus matrix protein M2 antibody
- M antibody
- M2 antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab94925 has not yet been referenced specifically in any publications.