Overview

  • Product nameAnti-ING3 antibody
    See all ING3 primary antibodies
  • Description
    Goat polyclonal to ING3
  • SpecificityTested on RKO cells transfected with ING3 (although a number of other bands were seen at similar weights). The immunogen sequence is not found in isoforms 2 and 3 listed in Q9NXR8.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Xenopus laevis
  • Immunogen

    Synthetic peptide:

    CADSRSGRKSKN

    , corresponding to amino acids 294 - 304 of Human ING3.

  • General notes


    ING3 is a tumor suppressor that acts as a potent growth regulator in normal and in established cells. p47 ING3 appears to modulate p53-mediated transcription, cell cycle control and apoptosis.

Properties

Applications

Our Abpromise guarantee covers the use of ab3713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 47 kDa.

Target

  • RelevanceING3 belongs to a family of proteins containing the plant homeodomain (PHD) finger, which includes transcription factors and proteins that regulate chromatin structure. ING3 is a component of the NuA4 histone acetyltransferase (HAT) complex and can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of ING3 has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of the ING3 gene were detected in head and neck cancers.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • 1300013A07Rik antibody
    • Eaf 4 antibody
    • Eaf4 antibody
    • FLJ20089 antibody
    • ING 2 antibody
    • ING 3 antibody
    • ING2 antibody
    • Inhibitor of growth family member 3 antibody
    • Inhibitor of growth protein 3 antibody
    • MEAF4 antibody
    • p47 ING 3 antibody
    • p47 ING3 antibody
    • p47 regulator protein antibody
    • p47ING3 antibody
    • p47ING3 protein antibody
    see all

Anti-ING3 antibody images

  • All lanes : Anti-ING3 antibody (ab3713) at 1/1000 dilution

    Lane 1 : RKO whole cell lysate
    Lane 2 : RKO cells transfected with ING3 - whole cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    IRDye 800 conjugated Rabbit anti-Goat IgG [H&L] at 1/10000 dilution

    Performed under reducing conditions.

    Predicted band size : 47 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)

References for Anti-ING3 antibody (ab3713)

ab3713 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"