Overview

  • Product nameAnti-ING4 antibody
    See all ING4 primary antibodies
  • Description
    Rabbit polyclonal to ING4
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to internal sequence amino acids 33-183 of Human ING4, isoform 3 (BC007781).

  • Positive control
    • Human fetal liver, fetal kidney and Mouse kidney lysates; Human fetal brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab113425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa).
IHC-P 1/100 - 1/500.

Target

  • FunctionComponent of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
  • Sequence similaritiesBelongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Brain my036 protein antibody
    • Candidate tumor suppressor p33 ING 1 homolog antibody
    • Candidate tumor suppressor p33 ING1 homolog antibody
    • D6Wsu147e antibody
    • D6Xrf92 antibody
    • ING 1 like protein antibody
    • ING 4 antibody
    • ING1 like protein antibody
    • ING4 antibody
    • ING4_HUMAN antibody
    • Inhibitor of growth family member 4 antibody
    • Inhibitor of growth family member 4 long isoform antibody
    • Inhibitor of growth protein 4 antibody
    • MGC12557 antibody
    • my036 antibody
    • p29 ING 4 antibody
    • p29 ING4 antibody
    • p29ING4 antibody
    see all

Anti-ING4 antibody images

  • All lanes : Anti-ING4 antibody (ab113425) at 1/500 dilution

    Lane 1 : Human fetal liver lysate
    Lane 2 : Human fetal kidney lysate
    Lane 3 : Mouse kidney lysate


    Predicted band size : 26 kDa
  • ab113425 at 1/100 dilution staining ING4 in Formalin-fixed, Paraffin-embedded Human fetal brain tissue by Immunohistochemistry. Note nuclear staining.

References for Anti-ING4 antibody (ab113425)

ab113425 has not yet been referenced specifically in any publications.

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