Overview

  • Product nameAnti-INPP5F antibody
    See all INPP5F primary antibodies
  • Description
    Rabbit polyclonal to INPP5F
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from N terminal domain of Human INPP5F protein

Properties

Applications

Our Abpromise guarantee covers the use of ab90620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 104 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionConverts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes.
  • Tissue specificityBrain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts.
  • Involvement in diseaseDefects in OCRL are the cause of Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]. It is an X-linked multisystem disorder affecting eyes, nervous system, and kidney. It is characterized by hydrophthalmia, cataract, mental retardation, vitamin D-resistant rickets, aminoaciduria, and reduced ammonia production by the kidney. Ocular abnormalities include cataract, glaucoma, microphthalmos, and decreased visual acuity. Developmental delay, hypotonia, behavior abnormalities, and areflexia are also present. Renal tubular involvement is characterized by impaired reabsorption of bicarbonate, amino acids, and phosphate. Musculoskeletal abnormalities such as joint hypermobility, dislocated hips, and fractures may develop as consequences of renal tubular acidosis and hypophosphatemia. Cataract is the only significant manifestation in carriers and is detected by slit-lamp examination.
    Defects in OCRL are the cause of Dent disease type 2 (DD2) [MIM:300555]. DD2 is a renal disease belonging to the 'Dent disease complex', a group of disorders characterized by proximal renal tubular defect, hypercalciuria, nephrocalcinosis, and renal insufficiency. The spectrum of phenotypic features is remarkably similar in the various disorders, except for differences in the severity of bone deformities and renal impairment. Characteristic abnormalities include low-molecular-weight proteinuria and other features of Fanconi syndrome, such as glycosuria, aminoaciduria, and phosphaturia, but typically do not include proximal renal tubular acidosis. Progressive renal failure is common, as are nephrocalcinosis and kidney stones.
  • Sequence similaritiesBelongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.
    Contains 1 Rho-GAP domain.
  • Cellular localizationEndosome. Also found on macropinosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 3.1.3.36 antibody
    • Inositol polyphosphate 5 phosphatase OCRL 1 antibody
    • Inositol polyphosphate 5 phosphatase OCRL1 antibody
    • Inositol polyphosphate 5-phosphatase OCRL-1 antibody
    • INPP5F antibody
    • LOCR antibody
    • Lowe oculocerebrorenal syndrome protein antibody
    • NPHL2 antibody
    • OCRL 1 antibody
    • OCRL antibody
    • OCRL_HUMAN antibody
    • OCRL1 antibody
    • Oculocerebrorenal syndrome of Lowe antibody
    • Phosphatidylinositol polyphosphate 5 phosphatase antibody
    see all

References for Anti-INPP5F antibody (ab90620)

ab90620 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab90620.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"