Overview

  • Product name
    Insig1 peptide

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab126817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Insig1 antibody (ab70784)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: PBS, 50% Glycerol, 1% BSA

General Info

  • Alternative names
    • CL 6
    • CL6
    • INSI1_HUMAN
    • INSIG 1
    • INSIG 1 membrane protein
    • INSIG-1
    • insig1
    • INSIG1 membrane protein
    • Insulin induced gene 1
    • Insulin induced gene 1 protein
    • Insulin-induced gene 1 protein
    • MGC1405
    see all
  • Function
    Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
  • Tissue specificity
    Expressed in all tissues tested with highest expression in the liver.
  • Sequence similarities
    Belongs to the INSIG family.
  • Post-translational
    modifications
    Ubiquitinated. Subsequent to sterol deprivation, the SCAP-SREBF2 complex becomes dissociated from INSIG1, is then ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it is not required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt

References

ab126817 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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