Overview

  • Product name
  • Description
    Rabbit polyclonal to INSL3
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human, Rhesus monkey
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide, corresponding to C terminal amino acids 115-131 of Human INSL3, differing from the related rat and mouse sequence by three amino acids.

  • Positive control
    • Human testicle sections

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide, 0.01% Thimerosal (merthiolate)
    Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab65981 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 14 kDa.
IHC-P Use a concentration of 1 - 2 µg/ml.

Target

  • Function
    Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
  • Tissue specificity
    Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.
  • Involvement in disease
    Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO) [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low.
  • Sequence similarities
    Belongs to the insulin family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • INSL 3 antibody
    • INSL3 antibody
    • INSL3_HUMAN antibody
    • Insulin like 3 antibody
    • insulin like peptide, Leydig cell-specific antibody
    • insulin-like 3 (Leydig cell) antibody
    • Insulin-like 3 A chain antibody
    • Ley IL antibody
    • Ley-I-L antibody
    • leydig insulin -like hormone antibody
    • Leydig insulin like peptide antibody
    • Leydig insulin-like peptide antibody
    • prepro-INSL3 antibody
    • Relaxin like factor antibody
    • Relaxin-like factor antibody
    • relaxin-like factor b antibody
    • RLF antibody
    • RLNL antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded human testicle staining INSL3 in cytoplasm using ab65981 at 2µg/ml. DAB chromogenic reaction.

References

This product has been referenced in:
  • Fouquet B  et al. Ovarian-like differentiation in eutopic and ectopic endometrioses with aberrant FSH receptor, INSL3 and GATA4/6 expression. BBA Clin 6:143-152 (2016). IHC-P ; Human . Read more (PubMed: 27882303) »
  • Hanna CB  et al. Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques. Reprod Biol Endocrinol 8:150 (2010). WB, IHC-P ; Rhesus monkey . Read more (PubMed: 21138583) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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