Anti-Insulin antibody [8E2] (ab1967)

Overview

  • Product nameAnti-Insulin antibody [8E2]
    See all Insulin primary antibodies
  • Description
    Mouse monoclonal [8E2] to Insulin
  • SpecificityKass for this antibody is 6.0 x 108M-1. It cross-reacts with human proinsulin. No cross-reaction with free C-peptide.
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human, Pig
    Predicted to work with: Cow
  • Immunogen

    Full length native protein (purified).

  • General notesConcentration varies from lot to lot and can be provided on request.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab1967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
  • Application notesELISA: Use at an assay dependent dilution.
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInsulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    • Involvement in diseaseDefects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
      Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
      Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
      Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    • Sequence similaritiesBelongs to the insulin family.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • IDDM1 antibody
      • IDDM2 antibody
      • ILPR antibody
      • ins antibody
      • INS_HUMAN antibody
      • Insulin A chain antibody
      • Insulin B chain antibody
      • IRDN antibody
      • MODY10 antibody
      • Preproinsulin antibody
      • Proinsulin antibody
      • Proinsulin precursor antibody
      see all

    References for Anti-Insulin antibody [8E2] (ab1967)

    ab1967 has not yet been referenced specifically in any publications.

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    I would be pleased to help with your enquiry. In order to do so, could you confirm which antibody you have contacted us about? Is this product code ab1967? Unfortunately, this antibody is no longer available and h...

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    Here is the rest of the information for your customer: Ab1968 - this clone (C7C9) reacts with the c-terminal pentapeptide of the insulin beta-chain. There is unfortunately no epitope information for ab1966 (clone 7F5). If you have any more questions ju...

    Read More

    Here is the rest of the information for your customer: Ab1968 - this clone (C7C9) reacts with the c-terminal pentapeptide of the insulin beta-chain. There is unfortunately no epitope information for ab1966 (clone 7F5). If you have any more questions ju...

    Read More

    Thanks for your patience with this one. Here is the epitope information - Ab7760: The epitope specificity was not performed. It reacts with high affinity with the whole insulin molecule (native, under the conditions of RIA) but with much lower affi...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"