Anti-Insulin degrading enzyme / IDE antibody (ab62829)

Overview

  • Product nameAnti-Insulin degrading enzyme / IDE antibody
    See all Insulin degrading enzyme / IDE primary antibodies
  • Description
    Goat polyclonal to Insulin degrading enzyme / IDE
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Cow, Human, Zebrafish
  • Immunogen

    Synthetic peptide:

    C-QQYNYDRDNIE

    , corresponding to internal sequence amino acids 914-924 of Mouse Insulin degrading enzyme/ IDE

  • Positive control
    • Mouse Brain lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab62829 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 118 kDa).
ELISA 1/16000.

Target

  • FunctionPlays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
  • Sequence similaritiesBelongs to the peptidase M16 family.
  • Post-translational
    modifications
    The N-terminus is blocked.
  • Cellular localizationCytoplasm. Cell surface. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
  • Information by UniProt
  • Database links
  • Alternative names
    • Abeta-degrading protease antibody
    • FLJ35968 antibody
    • Ide antibody
    • IDE_HUMAN antibody
    • Insulin protease antibody
    • Insulin-degrading enzyme antibody
    • Insulinase antibody
    • Insulysin antibody
    • OTTHUMP00000020097 antibody
    see all

Anti-Insulin degrading enzyme / IDE antibody images

  • Anti-Insulin degrading enzyme / IDE antibody (ab62829) at 1 µg/ml + Mouse brain lysate at 35 µg

    Predicted band size : 118 kDa
    Observed band size : 110 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Insulin degrading enzyme / IDE antibody (ab62829)

ab62829 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"