Overview

  • Product name
  • Description
    Rabbit polyclonal to INT11
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Chimpanzee, Rhesus monkey, Gorilla, Opossum, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region within the amino acids 550-600 of Human INT11, NP_060341.2

  • Positive control
    • Human breast carcinoma, prostate carcinoma.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab84719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage.
    • Sequence similarities
      Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
    • Domain
      The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.
    • Cellular localization
      Nucleus. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2410006F12Rik antibody
      • AU044035 antibody
      • Cleavage and polyadenylation specific factor 3 like antibody
      • Cleavage and polyadenylation-specific factor 3-like protein antibody
      • CPSF3 like protein antibody
      • CPSF3-like protein antibody
      • CPSF3L antibody
      • CPSF73L antibody
      • FLJ13294 antibody
      • FLJ20542 antibody
      • Human integrator complex subunit 11 antibody
      • INT 11 antibody
      • Int11 antibody
      • INT11_HUMAN antibody
      • Integrator complex subunit 11 antibody
      • INTS 11 antibody
      • INTS11 antibody
      • MGC124975 antibody
      • OTTHUMP00000044092 antibody
      • Protein related to CPSF subunits of 68 kDa antibody
      • RC 68 antibody
      • RC 68, related antibody
      • RC-68 antibody
      • RC68 antibody
      • Related to CPSF subunits 68 kDa antibody
      • Related to CPSF subunits, 68 kDa protein antibody
      • RGD1306841 antibody
      • RP23 242K15.19 antibody
      see all

    Images

    • Detection of Human INT11 by Immunohistochemistry.
      Sample: FFPE section of Human breast carcinoma.
      Antibody: ab84719 used at a dilution of 1/250.
      Detection: DAB staining.

    References

    ab84719 has not yet been referenced specifically in any publications.

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    There are currently no Customer reviews or Questions for ab84719.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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