Overview

  • Product nameAnti-Integrin alpha 1 antibody [TS2/7]
    See all Integrin alpha 1 primary antibodies
  • Description
    Mouse monoclonal [TS2/7] to Integrin alpha 1
  • Specificityab34445 recognises alpha 1 integrin subunit.
  • Tested applicationsSuitable for: Flow Cyt, IHC-Fr, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Integrin alpha 1 subunit.

  • Positive control
    • HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab34445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/25 - 1/50. Use 10µl of the suggested working dilution to label 106 cells in 100µl.



ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-Fr Use at an assay dependent concentration.
IP Use at an assay dependent concentration.

Target

  • FunctionIntegrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
  • Sequence similaritiesBelongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 49a antibody
    • CD49 antigen-like family member A antibody
    • CD49a antibody
    • CD49a antigen antibody
    • Integrin alpha-1 antibody
    • ITA1_HUMAN antibody
    • Itga 1 antibody
    • ITGA1 antibody
    • Laminin and collagen receptor antibody
    • Very late activation protein 1 antibody
    • VLA 1 antibody
    • VLA-1 antibody
    • VLA1 antibody
    see all

Anti-Integrin alpha 1 antibody [TS2/7] images

  • Staining of HeLa cells with MOUSE ANTI HUMAN CD49a (ab34445).

References for Anti-Integrin alpha 1 antibody [TS2/7] (ab34445)

This product has been referenced in:
  • Chen X  et al. Integrin-mediated type II TGF-ß receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest 124:3295-310 (2014). IHC-Fr, Flow Cyt ; Human . Read more (PubMed: 24983314) »

See 1 Publication for this product

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (Tumour Cells)
Specification Tumour Cells
Fixative Paraformaldehyde
Permeabilization No
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 1% · Temperature: RT°C
Username

Dr. Sharon Sneddon

Verified customer

Submitted Jul 11 2008

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"