Anti-Integrin alpha 2 antibody [DX5] (Phycoerythrin) (ab25493)


  • Product nameAnti-Integrin alpha 2 antibody [DX5] (Phycoerythrin)
    See all Integrin alpha 2 primary antibodies
  • Description
    Rat monoclonal [DX5] to Integrin alpha 2 (Phycoerythrin)
  • ConjugationPhycoerythrin. Ex: 488nm, Em: 575nm
  • Specificityab25493 recognises integrin alpha 2.
  • Tested applicationsSuitable for: Flow Cytmore details
    Unsuitable for: IHC-Fr or IHC-P
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue/ cell preparation: RIL 2 propagated NK1.1 positive cells from C57BL/6 mice.

  • General notes

    NK cells cultured in the presence of IL2 progressively lose reactivity with DX5 as a consequence of cellular proliferation. Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. DX5 has not been demonstrated to have activating or blocking activity.



Our Abpromise guarantee covers the use of ab25493 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.2µg for 106 cells.

ab25493 can be used to define functionally distinct subsets of murine NK cells.

  • Application notesIs unsuitable for IHC-Fr or IHC-P.
  • Target

    • FunctionIntegrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
    • Sequence similaritiesBelongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
      Contains 1 VWFA domain.
    • DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • BR antibody
      • CD 49b antibody
      • CD49 antigen like family member B antibody
      • CD49 antigen-like family member B antibody
      • CD49b antibody
      • CD49b antigen antibody
      • Collagen receptor antibody
      • DX5 antibody
      • Glycoprotein Ia deficiency included antibody
      • GP Ia antibody
      • GP Ia deficiency, included antibody
      • GPIa antibody
      • HPA 5 included antibody
      • HPA5 included antibody
      • Human platelet alloantigen system 5 antibody
      • Integrin alpha 2 antibody
      • Integrin alpha-2 antibody
      • Integrin, alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor) antibody
      • ITA2_HUMAN antibody
      • ITGA2 antibody
      • Platelet alloantigen Br(a), included antibody
      • Platelet antigen Br antibody
      • Platelet glycoprotein GPIa antibody
      • Platelet glycoprotein Ia antibody
      • Platelet glycoprotein Ia/IIa antibody
      • Platelet membrane glycoprotein Ia antibody
      • Platelet receptor for collagen, deficiency of, included antibody
      • Very late activation protein 2 receptor alpha 2 subunit antibody
      • VLA 2 alpha chain antibody
      • VLA 2 antibody
      • VLA 2 subunit alpha antibody
      • VLA-2 subunit alpha antibody
      • VLA2 antibody
      • VLA2 receptor alpha 2 subunit antibody
      • VLAA2 antibody
      see all

    References for Anti-Integrin alpha 2 antibody [DX5] (Phycoerythrin) (ab25493)

    This product has been referenced in:
    • Arase H  et al. Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2). J Immunol 167:1141-4 (2001). Read more (PubMed: 11466327) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab25493.
    Please use the links above to contact us or submit feedback about this product.