Anti-Integrin alpha 3 antibody [VJ1/6] (CF405M) (ab115912)

Overview

  • Product nameAnti-Integrin alpha 3 antibody [VJ1/6] (CF405M)
    See all Integrin alpha 3 primary antibodies
  • Description
    Mouse monoclonal [VJ1/6] to Integrin alpha 3 (CF405M)
  • ConjugationCF405M. Ex: 408nm, Em: 452nm
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    TNF-activated HUVEC

  • Positive control
    • Human platelets.
  • General notes

    CF405M (Abs/Em Max: 408/450 nm) US patent application no. 12/607,915. CF405M (Abs/Em Max: 408/450nm). Direct replacement for Pacific Blue dye®, BD Horizon™ V450.

Properties

Applications

Our Abpromise guarantee covers the use of ab115912 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 5µl for 106 cells. ab126026-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionIntegrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
  • Tissue specificityIsoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
  • Sequence similaritiesBelongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • Post-translational
    modifications
    Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. Isoform alpha-3A is phosphorylated on Tyr-1051.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AA407068 antibody
    • Antigen identified by monoclonal antibody J143 antibody
    • CD49 antigen like family member C antibody
    • CD49 antigen-like family member C antibody
    • CD49c antibody
    • CD49c antigen antibody
    • FLJ34631 antibody
    • FLJ34704 antibody
    • FRP 2 antibody
    • FRP-2 antibody
    • FRP2 antibody
    • Galactoprotein B3 antibody
    • GAP B3 antibody
    • GAPB3 antibody
    • Integrin alpha 3 antibody
    • Integrin alpha-3 light chain antibody
    • Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) antibody
    • ITA3_HUMAN antibody
    • ITGA 3 antibody
    • Itga3 antibody
    • MSK18 antibody
    • VCA 2 antibody
    • VCA2 antibody
    • Very late activation protein 3 receptor alpha 3 subunit antibody
    • VL3A antibody
    • VLA 3 alpha chain antibody
    • VLA 3 subunit alpha antibody
    • VLA-3 subunit alpha antibody
    • VLA3a antibody
    see all

Anti-Integrin alpha 3 antibody [VJ1/6] (CF405M) images

  • ab115912 at 5µl/106 cells staining Integrin alpha 3 in Human platelets cells by Flow Cytometry (shown in red).
    Total events were used for analysis (left image).

References for Anti-Integrin alpha 3 antibody [VJ1/6] (CF405M) (ab115912)

ab115912 has not yet been referenced specifically in any publications.

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