The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesBL: Use at an assay dependent dilution.
Flow Cyt: Use <0.1µg for 106 cells.
IHC-Fr: Use at an assay dependent dilution.
Induction of homotypic cellular aggregation.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceIntegrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria.
Cellular localizationMembrane; Single pass type I membrane protein.