Anti-Integrin alpha 4+beta 7 antibody [DATK32] (Phycoerythrin) (ab25080)

Overview

  • Product nameAnti-Integrin alpha 4+beta 7 antibody [DATK32] (Phycoerythrin)
    See all Integrin alpha 4+beta 7 primary antibodies
  • Description
    Rat monoclonal [DATK32] to Integrin alpha 4+beta 7 (Phycoerythrin)
  • ConjugationPhycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applicationsSuitable for: Flow Cyt, Blocking, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue/ cell preparation: AKR/Cum spontaneous T lymphoma cell line TK1 (Mouse).

  • EpitopeThis antibody recognizes a conformational epitope on the alpha 4 beta 7 heterodimer.

Properties

Applications

Our Abpromise guarantee covers the use of ab25080 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
Blocking
IHC-Fr
  • Application notesBL: Use at an assay dependent dilution.
    Flow Cyt: Use <0.1µg for 106 cells.
    IHC-Fr: Use at an assay dependent dilution.
    Induction of homotypic cellular aggregation.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceIntegrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria.
    • Cellular localizationMembrane; Single pass type I membrane protein.
    • Database links
    • Alternative names
      • Antigen CD49D antibody
      • CD49d antibody
      • IA4 antibody
      • Integrin alpha 4 subunit antibody
      • Integrin alpha IV antibody
      • Integrin beta 7 antibody
      • Integrin beta 7 subunit antibody
      • ITGA4 antibody
      • ITGB7 antibody
      • LPAM1 antibody
      see all

    Anti-Integrin alpha 4+beta 7 antibody [DATK32] (Phycoerythrin) images

    • Flow cytometry analysis staining Integrin alpha 4+beta 7 in T-lymphocyte cell line TK-1 using ab25080 at a dilution of 0.1 ug/106 cells. Rat Anti-Mouse LPAM-1-PE was used as an isotype control.

    References for Anti-Integrin alpha 4+beta 7 antibody [DATK32] (Phycoerythrin) (ab25080)

    ab25080 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"