Anti-Integrin alpha V antibody [13C2] (ab78613)

Overview

  • Product name
    Anti-Integrin alpha V antibody [13C2]
    See all Integrin alpha V primary antibodies
  • Description
    Mouse monoclonal [13C2] to Integrin alpha V
  • Specificity
    ab78613 reacts with Integrin alpha V found in osteoclasts, placenta and melanoma cell lines, some endothelial cells, smooth muscle cells and fibroblasts, and weakly in platelets.
  • Tested applications
    Suitable for: IHC-Fr, Flow Cyt, Purificationmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human osteoclastoma tissue

  • Positive control
    • Human tonsil.

Properties

Applications

Our Abpromise guarantee covers the use of ab78613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr
Flow Cyt
Purification
  • Application notes
    Flow Cyt: Use at an assay dependent dilution.
    IHC-Fr: Use at an assay dependent dilution.
    P: Use at an assay dependent dilution. ab78613 can be used for purification of the vitronectin receptor.

    Note: ab78613 can be used for the following studies:
    Bone resorption modulation
    Osteoclast identification
    Malignant melanoma identification (and possible treatment)


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    • Sequence similarities
      Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • antigen identified by monoclonal antibody L230 antibody
      • CD 51 antibody
      • CD51 antibody
      • DKFZp686A08142 antibody
      • Integrin alpha five antibody
      • integrin alpha V beta 3 antibody
      • Integrin alpha-5 antibody
      • integrin alpha-V antibody
      • Integrin alpha-V light chain antibody
      • integrin alphaVbeta3 antibody
      • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody
      • ITAV_HUMAN antibody
      • ITGAV antibody
      • MSK 8 antibody
      • Msk8 antibody
      • Vitronectin receptor subunit alpha antibody
      • VNRA antibody
      • VTNR antibody
      see all

    Images

    • ab78613 staining Integrin alpha V in blood vessel endothelium in frozen section of human tonsil.

    References

    ab78613 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab78613.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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