The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesFlow Cyt: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
P: Use at an assay dependent dilution. ab78613 can be used for purification of the vitronectin receptor.
Note: ab78613 can be used for the following studies:
Bone resorption modulation
Malignant melanoma identification (and possible treatment)
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionThe alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Sequence similaritiesBelongs to the integrin alpha chain family. Contains 7 FG-GAP repeats.