Overview

  • Product nameAnti-Integrin alpha V antibody
    See all Integrin alpha V primary antibodies
  • Description
    Rabbit polyclonal to Integrin alpha V
  • Specificityab117611 detects endogenous levels of fragment of activated Integrin alpha V resulting from cleavage adjacent to Lys889.
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH corresponding to C terminal residues of Human Integrin alpha V (NP_002201.1).

  • Positive control
    • Human Placenta and Thyroid tissues; A549 cell extracts, treated with etoposide.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab117611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 116 kDa.
ELISA 1/10000.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionThe alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
  • Sequence similaritiesBelongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • antigen identified by monoclonal antibody L230 antibody
    • CD 51 antibody
    • CD51 antibody
    • DKFZp686A08142 antibody
    • integrin alpha V beta 3 antibody
    • integrin alpha-V antibody
    • Integrin alpha-V light chain antibody
    • integrin alphaVbeta3 antibody
    • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody
    • ITAV_HUMAN antibody
    • ITGAV antibody
    • MSK 8 antibody
    • Msk8 antibody
    • Vitronectin receptor subunit alpha antibody
    • VNRA antibody
    • VTNR antibody
    see all

Anti-Integrin alpha V antibody images

  • ab117611, at 5 µg/ml, staining Integrin alpha V in Formalin-fixed, Paraffin-embedded Human Thyroid tissue by Immunohistochemistry.
  • ab117611, at 5 µg/ml, staining Integrin alpha V in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry.
  • All lanes : Anti-Integrin alpha V antibody (ab117611) at 1/500 dilution

    Lane 1 : A549 cell extracts, treated with etoposide 25uM 1hr
    Lane 2 : A549 cell extracts, treated with etoposide 25uM 1h with synthetic peptide


    Predicted band size : 116 kDa

References for Anti-Integrin alpha V antibody (ab117611)

This product has been referenced in:

See 1 Publication for this product

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step Blockace as blocking agent for 10 minute(s) · Concentration: 4% · Temperature: 20°C
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: citrate buffer solution
Sample Dog Tissue sections (Thyroid tissues)
Specification Thyroid tissues
Permeabilization No
Fixative Formaldehyde
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Submitted Jul 14 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"