Overview

  • Product name
    Anti-Integrin alpha V beta 3 antibody [23C6]
    See all Integrin alpha V beta 3 primary antibodies
  • Description
    Mouse monoclonal [23C6] to Integrin alpha V beta 3
  • Specificity
    Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
  • Tested applications
    Suitable for: Flow Cyt, IP, Neutralising, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Cell preparation: A cell suspension containing osteoclasts from osteoclastomas.

  • Positive control
    • Positive control: Tonsil. 125/124 kDa (reduced), 150kDa (non-reduced).

Properties

Applications

Our Abpromise guarantee covers the use of ab20143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
IP
Neutralising
IHC-Fr
  • Application notes
    Flow Cyt: Use at an assay dependent dilution.
    IHC-Fr: Use at an assay dependent dilution.
    Note: samples should be acetone fixed.
    IP: Use at an assay dependent dilution.
    Neut: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Function: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C (PubMed:20615244). Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1 (PubMed:9426447, PubMed:15194773, PubMed:7519807). Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 (PubMed:24367260). Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for West nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733). Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats.
    • Cellular localization
      Cell Membrane. Cytoplasmic. Integrin complex. Focal adhesion.
    • Database links
    • Alternative names
      • Antigen identified by monoclonal antibody L230 antibody
      • CD 51 antibody
      • CD 61 antibody
      • CD51 antibody
      • CD51 antigen antibody
      • CD61 antibody
      • CD61 antigen antibody
      • DKFZp686A08142 antibody
      • GP3A antibody
      • GPIIIa antibody
      • Integrin alpha V antibody
      • Integrin alpha V vitronectin receptor alpha polypeptide antibody
      • Integrin alpha V vitronectin receptor alpha polypeptide antigen CD51 antibody
      • integrin alpha-V antibody
      • Integrin alpha-V light chain antibody
      • Integrin beta 3 antibody
      • Integrin beta 3 platelet glycoprotein IIIa antigen CD61 antibody
      • Integrin beta chain beta 3 antibody
      • integrinVbeta3 antibody
      • ITAV_HUMAN antibody
      • ITGAV antibody
      • ITGB 3 antibody
      • ITGB3 antibody
      • MSK 8 antibody
      • MSK8 antibody
      • Platelet glycoprotein IIIa antibody
      • Platelet glycoprotein IIIa precursor antibody
      • Platelet membrane glycoprotein IIIa antibody
      • Vitronectin receptor alpha polypeptide antibody
      • vitronectin receptor antibody
      • Vitronectin receptor subunit alpha antibody
      • VNR 1 antibody
      • VNR1 antibody
      • VNRA antibody
      see all

    References

    This product has been referenced in:
    • Martino MM  et al. Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials 30:1089-97 (2009). Read more (PubMed: 19027948) »
    • Scarlett A  et al. Thyroid hormone stimulation of extracellular signal-regulated kinase and cell proliferation in human osteoblast-like cells is initiated at integrin alphaVbeta3. J Endocrinol 196:509-17 (2008). Read more (PubMed: 18310446) »

    See all 6 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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