Anti-integrin beta 4 binding protein antibody (ab116364)

Overview

  • Product nameAnti-integrin beta 4 binding protein antibody
    See all Integrin beta 4 binding protein primary antibodies
  • Description
    Rabbit polyclonal to integrin beta 4 binding protein
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Saccharomyces cerevisiae, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (AVRASFENNC EIGCFAKLTN TYCLVAIGGS ENFYSVFEGE LSDTIPVVHA) of Human integrin beta 4 binding protein (NP_002203).

  • Positive control
    • HeLa cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab116364 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionBinds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.
  • Tissue specificityExpressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).
  • Sequence similaritiesBelongs to the eIF-6 family.
  • Post-translational
    modifications
    Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
  • Cellular localizationCytoplasm. Nucleus > nucleolus. Shuttles between cytoplasm and nucleus/nucleolus.
  • Information by UniProt
  • Database links
  • Alternative names
    • b(2)gcn antibody
    • B(2)GCN homolog antibody
    • B4 integrin interactor antibody
    • Binding protein of beta-4 integrin antibody
    • CAB antibody
    • eIF-6 antibody
    • EIF3A antibody
    • EIF6 antibody
    • Eukaryotic translation initiation factor 3A antibody
    • Eukaryotic translation initiation factor 6 antibody
    • IF6_HUMAN antibody
    • ITGB4BP antibody
    • OK/SW-cl.27 antibody
    • p27 beta 4 integrin binding protein antibody
    • p27(BBP) antibody
    • p27BBP antibody
    • RP4-614O4.1 antibody
    see all

Anti-integrin beta 4 binding protein antibody images

  • Anti-integrin beta 4 binding protein antibody (ab116364) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size : 27 kDa
    Gel concentration: 12%.


  • Predicted band size : 27 kDa
    WB Suggested Anti-EIF6 antibody (116364) Titration: 2 µg/ml Positive Control: Xenopus laevis embryos

References for Anti-integrin beta 4 binding protein antibody (ab116364)

ab116364 has not yet been referenced specifically in any publications.

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