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Product name
Anti-integrin beta 4 binding protein antibody
See all Integrin beta 4 binding protein products (6) ...
Description
Chicken polyclonal to integrin beta 4 binding protein
Tested applications
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Immunogen corresponds to amino acids 74-175 of integrin beta 4 binding protein.
Positive control
HeLa and 293 cell lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgY
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Mediator Complex
Neuroscience >> Cell Adhesion Proteins >> Receptors >> Integrins >> Beta Integrins
-
Western blot - integrin beta 4 binding protein antibody (ab37598)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab37598 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500. Predicted molecular weight: 27 kDa.
Target
Function
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.
Tissue specificity
Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).
Sequence similarities
Belongs to the eIF-6 family.
Post-translational
modifications
Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
Cellular localization
Cytoplasm. Nucleus > nucleolus. Shuttles between cytoplasm and nucleus/nucleolus.
Target information above from: UniProt accessionP56537
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- b(2)gcn antibody
- B(2)GCN homolog antibody
- B4 integrin interactor antibody
see all
Database links
- Entrez Gene: 3692 Human
- Entrez Gene: 16418 Mouse
- Omim: 602912 Human
- SwissProt: P56537 Human
- SwissProt: O55135 Mouse
- Unigene: 654848 Human
- Unigene: 271674 Mouse
Anti-integrin beta 4 binding protein antibody images:
Western blot - integrin beta 4 binding protein antibody (ab37598)
All lanes : Anti-integrin beta 4 binding protein antibody (ab37598) at 1/500 dilution
Lane 1 : HeLa cell line (A)
Lane 2 : 293 cell line (B)
Secondary
Goat anti-IgY-HRP at 1/1000 dilution
Predicted band size : 27 kDa
References for Anti-integrin beta 4 binding protein antibody (ab37598)
This product has been referenced in:
- Wong CC et al. Defective ribosome assembly in Shwachman-Diamond syndrome. Blood 118:4305-12 (2011). WB; Human.Read more (PubMed: 21803848) »
See 1 publication for this product
Publishing research using ab37598? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"