Overview

  • Product name
    Anti-Interferon gamma antibody [7B6]
    See all Interferon gamma primary antibodies
  • Description
    Mouse monoclonal [7B6] to Interferon gamma
  • Specificity
    ab27919 recognises native and recombinant Interferon gamma.
  • Tested applications
    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ELISA
  • Species reactivity
    Reacts with: Cow
  • Immunogen

    The details of the immunogen for this antibody are not available.

Properties

Applications

Our Abpromise guarantee covers the use of ab27919 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Flow Cyt
  • Application notes
    FACS: Use 10µl for 106 cells in 100µl.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 19 kDa.

    Is unsuitable for ELISA.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • Tissue specificity
      Released primarily from activated T lymphocytes.
    • Involvement in disease
      In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • Sequence similarities
      Belongs to the type II (or gamma) interferon family.
    • Post-translational
      modifications
      Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    References for Anti-Interferon gamma antibody [7B6] (ab27919)

    This product has been referenced in:
    • Weynants V  et al. Quantitative assessment by flow cytometry of T-lymphocytes producing antigen-specific gamma-interferon in Brucella immune cattle. Vet Immunol Immunopathol 66:309-20 (1998). Read more (PubMed: 9880107) »
    • Broquié G [Tuberculosis infection] Soins 23:3-5, 8 (1978). Read more (PubMed: 98846) »

    See all 2 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab27919.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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