Anti-Interferon gamma antibody [DB-1] (ab22543)

Overview

  • Product nameAnti-Interferon gamma antibody [DB-1]
    See all Interferon gamma primary antibodies
  • Description
    Mouse monoclonal [DB-1] to Interferon gamma
  • SpecificityThis antibody reacts with both mouse and rat Interferon gamma. Clone DB-1 exhibits high affinity binding to the natural and recombinant forms and effectively neutralises the anti viral activity of IFN-gamma. It also blocks the induction of La antigen expression on murine keratinocytes.
  • Tested applicationsSuitable for: ELISA, Blocking, Neutralisingmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Recombinant full length rat IFN gamma

Properties

Applications

Our Abpromise guarantee covers the use of ab22543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
Blocking
Neutralising
  • Application notesBL: Use at an assay dependent dilution
    ELISA: Use at a concentration of 10 µg/ml, 100ul/well as coating antibody
    Neut: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProduced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • Tissue specificityReleased primarily from activated T lymphocytes.
    • Involvement in diseaseIn Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • Sequence similaritiesBelongs to the type II (or gamma) interferon family.
    • Post-translational
      modifications
      Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    References for Anti-Interferon gamma antibody [DB-1] (ab22543)

    ab22543 has not yet been referenced specifically in any publications.

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