Overview

  • Product name
    Anti-Interferon gamma antibody [XMG1.2]
    See all Interferon gamma primary antibodies
  • Description
    Rat monoclonal [XMG1.2] to Interferon gamma
  • Tested applications
    Suitable for: Flow Cyt, ELISAmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    E. coli expressed, recombinant mouse IFN gamma.

Properties

Applications

Our Abpromise guarantee covers the use of ab23637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
ELISA
  • Application notes
    ELISA: Use at an assay dependent dilution.
    Flow Cyt: Membrane permeablisation is required for this application. Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • Tissue specificity
      Released primarily from activated T lymphocytes.
    • Involvement in disease
      In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • Sequence similarities
      Belongs to the type II (or gamma) interferon family.
    • Post-translational
      modifications
      Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    References for Anti-Interferon gamma antibody [XMG1.2] (ab23637)

    This product has been referenced in:
    • Zhou Y  et al. MicroRNA-29a induces insulin resistance by targeting PPARd in skeletal muscle cells. Int J Mol Med 37:931-8 (2016). WB ; Rat . Read more (PubMed: 26936652) »
    • Hsieh B  et al. In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells. J Immunol 156:232-7 (1996). Read more (PubMed: 8598467) »

    See all 3 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab23637.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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