Anti-Interferon gamma [D9D10] antibody (Phycoerythrin) (ab11732)

Overview

  • Product nameAnti-Interferon gamma [D9D10] antibody (Phycoerythrin)See all Interferon gamma primary antibodies ...
  • Description
    Mouse monoclonal [D9D10] to Interferon gamma (Phycoerythrin)
  • ConjugationPhycoerythrin. Ex: 488nm, Em: 575nm
  • SpecificityThis antibody recognises both natural and recombinant human Interferon gamma, binding only to the dimeric (functional) form.
  • Tested applicationsFlow Cyt more details
  • Species reactivity
    Reacts with: Human, Baboon
  • Immunogen

    Full length native protein (purified) (Human).

  • General notesThis product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Properties

Applications

Our Abpromise guarantee covers the use of ab11732 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Flow Cyt
  • Application notesFlow Cyt: undiluted - 1/10. Use 10 µl of the suggested working dilution to label 106 cells in 100 µl. Membrane permeabilization is required for this application.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProduced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • Tissue specificityReleased primarily from activated T lymphocytes.
    • Involvement in diseaseIn Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • Sequence similaritiesBelongs to the type II (or gamma) interferon family.
    • Post-translational
      modifications
      Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • Cellular localizationSecreted.
    • Target information above from: UniProt accession P01579 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • IFG antibody
      • IFI antibody
      • IFN Gamma antibody
      • IFN Immune antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune Interferon antibody
      • Interferon gamma antibody
      • Interferon Gamma Precursor antibody
      • Macrophage Activating Factor antibody
      • MAF antibody
      • T Cell Interferon antibody
      • Type II Interferon antibody
      see all

    References for Anti-Interferon gamma [D9D10] antibody (Phycoerythrin) (ab11732)

    ab11732 has not yet been referenced specifically in any publications.

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