Anti-Interferon Receptor alpha antibody (ab180812)

Overview

  • Product name
    Anti-Interferon Receptor alpha antibody
    See all Interferon Receptor alpha primary antibodies
  • Description
    Rabbit polyclonal to Interferon Receptor alpha
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Interferon Receptor alpha aa 28-290.
    Sequence:

    KNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ


    Database link: P17181

  • Positive control
    • HeLa, HepG2 and SW480 cell line extracts

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab180812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

WB 1/500 - 1/2000. Predicted molecular weight: 64 kDa.

Target

  • Relevance
    Interferon Receptor alpha (IFN-a R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, Interferon Receptor alpha is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-a R). Interferon Receptor alpha is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of Interferon Receptor alpha complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on Interferon Receptor alpha. IFNAR1 possesses a large N-glycosylated ectodomain.
  • Cellular localization
    Membrane; single-pass type I membrane protein.
  • Database links
  • Alternative names
    • AVP antibody
    • IFN alpha R1 antibody
    • IFN alpha REC antibody
    • IFNAR antibody
    • IFNAR1 antibody
    • IFNBR antibody
    • IFRC antibody
    • interferon (alpha beta and omega) receptor 1 antibody
    • Interferon alpha receptor 1 antibody
    • Interferon alpha/beta receptor alpha chain antibody
    see all

Images

  • All lanes : Anti-Interferon Receptor alpha antibody (ab180812) at 1/500 dilution

    Lane 1 : HeLa cell line extracts
    Lane 2 : HepG2 cell line extracts
    Lane 3 : SW480 cell line extracts

    Predicted band size: 64 kDa

References

ab180812 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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