Anti-Interferon Receptor alpha antibody [MM0336-8H46] (ab90498)

Overview

  • Product name
    Anti-Interferon Receptor alpha antibody [MM0336-8H46]
    See all Interferon Receptor alpha primary antibodies
  • Description
    Mouse monoclonal [MM0336-8H46] to Interferon Receptor alpha
  • Tested applications
    Suitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to the extracellular domain of Human Interferon Receptor alpha.

  • Positive control
    • U937 human lymphoma cell line.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • Clonality
    Monoclonal
  • Clone number
    MM0336-8H46
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 64 kDa.
Flow Cyt 1/50 - 1/200. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • Relevance
    Interferon Receptor alpha (IFN-a R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, Interferon Receptor alpha is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-a R). Interferon Receptor alpha is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of Interferon Receptor alpha complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on Interferon Receptor alpha. IFNAR1 possesses a large N-glycosylated ectodomain.
  • Cellular localization
    Membrane; single-pass type I membrane protein.
  • Database links
  • Alternative names
    • AVP antibody
    • IFN alpha R1 antibody
    • IFN alpha REC antibody
    • IFNAR antibody
    • IFNAR1 antibody
    • IFNBR antibody
    • IFRC antibody
    • interferon (alpha beta and omega) receptor 1 antibody
    • Interferon alpha receptor 1 antibody
    • Interferon alpha/beta receptor alpha chain antibody
    see all

References

ab90498 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for contacting us. The lab tested this antibody in Flow Cytometry on the U937 human lymphoma cell line. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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