Anti-Interferon Receptor alpha antibody [MM0336-8H46] (ab90498)

Overview

  • Product nameAnti-Interferon Receptor alpha antibody [MM0336-8H46]
    See all Interferon Receptor alpha primary antibodies
  • Description
    Mouse monoclonal [MM0336-8H46] to Interferon Receptor alpha
  • Tested applicationsSuitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to the extracellular domain of Human Interferon Receptor alpha.

  • Positive control
    • U937 human lymphoma cell line.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • ClonalityMonoclonal
  • Clone numberMM0336-8H46
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 64 kDa.
Flow Cyt 1/50 - 1/200. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • RelevanceInterferon Receptor alpha (IFN-a R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, Interferon Receptor alpha is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-a R). Interferon Receptor alpha is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of Interferon Receptor alpha complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on Interferon Receptor alpha. IFNAR1 possesses a large N-glycosylated ectodomain.
  • Cellular localizationMembrane; single-pass type I membrane protein.
  • Database links
  • Alternative names
    • AVP antibody
    • IFN alpha R1 antibody
    • IFN alpha REC antibody
    • IFNAR antibody
    • IFNAR1 antibody
    • IFNBR antibody
    • IFRC antibody
    • interferon (alpha beta and omega) receptor 1 antibody
    • Interferon alpha receptor 1 antibody
    • Interferon alpha/beta receptor alpha chain antibody
    see all

References for Anti-Interferon Receptor alpha antibody [MM0336-8H46] (ab90498)

ab90498 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. The lab tested this antibody in Flow Cytometry on the U937 human lymphoma cell line. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"