ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionCytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.
Tissue specificityDetected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
ab101443, at 1/200 dilution, staining Interleukin 34 in U251 cells by Immunofluorescence analysis (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
ab101443 staining Interleukin 34 in K562 cells (green) at 1/200 by Flow cytometry. Negative control (purple).
References for Anti-Interleukin 34 antibody [1D12] (ab101443)
This product has been referenced in:
Baghdadi M et al. Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells. Cancer Res76:6030-6042 (2016).
Read more (PubMed: 27550451) »
Shoji H et al. Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease. Sci Rep6:28814 (2016).
Read more (PubMed: 27363523) »