Anti-IL-34 antibody (ab111978)
Key features and details
- Rabbit polyclonal to IL-34
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-IL-34 antibody
See all IL-34 primary antibodies -
Description
Rabbit polyclonal to IL-34 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant full length protein corresponding to Human IL-34 aa 21-242. (BC029804)
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Positive control
- Human fetal spleen tissue; Human fetal brain lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab111978 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 27 kDa).
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Notes |
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WB
1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 27 kDa). |
Target
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Function
Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R. -
Tissue specificity
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon. -
Sequence similarities
Belongs to the IL-34 family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 146433 Human
- Entrez Gene: 76527 Mouse
- Entrez Gene: 498951 Rat
- Omim: 612081 Human
- SwissProt: Q6ZMJ4 Human
- SwissProt: Q8R1R4 Mouse
- SwissProt: Q4KM46 Rat
- Unigene: 461214 Human
see all -
Alternative names
- C16orf77 antibody
- Chromosome 16 open reading frame 77 antibody
- FPT025 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab111978 has been referenced in 1 publication.
- Ciccia F et al. IL-34 is overexpressed in the inflamed salivary glands of patients with Sjogren's syndrome and is associated with the local expansion of pro-inflammatory CD14brightCD16+ monocytes. Rheumatology (Oxford) 52:1009-17 (2013). IHC-P ; Human . PubMed: 23392590