Overview

  • Product name
    Iodotubercidin
  • Description
    Potent, adenosine kinase inhibitor
  • Biological description
    Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Pignataro G  et al. Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J Cereb Blood Flow Metab 27:1-5 (2007). Read more (PubMed: 16685255) »
  • García-Villafranca J & Castro J Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol 63:1997-2000 (2002). Read more (PubMed: 12093476) »
  • Ugarkar BG  et al. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem 43:2883-93 (2000). Read more (PubMed: 10956196) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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