Anti-Ionotropic Glutamate receptor 4 (phospho S862) antibody (ab61054)

Overview

  • Product name
    Anti-Ionotropic Glutamate receptor 4 (phospho S862) antibody
    See all Ionotropic Glutamate receptor 4 primary antibodies
  • Description
    Rabbit polyclonal to Ionotropic Glutamate receptor 4 (phospho S862)
  • Specificity
    Detects target only when phosphorylated at serine 862.
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic phosphopeptide derived from human ionotropic Glutamate Receptor 4 around the phosphorylation site of serine 862 (R-L-SP-I-T)

Properties

Applications

Our Abpromise guarantee covers the use of ab61054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 102 kDa (predicted molecular weight: 102 kDa).
ELISA 1/5000.

Target

  • Function
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
  • Sequence similarities
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
  • Post-translational
    modifications
    Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • Cellular localization
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AMPA 4 antibody
    • AMPA selective glutamate receptor 4 antibody
    • AMPA-selective glutamate receptor 4 antibody
    • AMPA4 antibody
    • GluA 4 antibody
    • GluA4 antibody
    • GluR 4 antibody
    • GluR D antibody
    • GluR-4 antibody
    • GluR-D antibody
    • GluR4 antibody
    • GLUR4C antibody
    • GLURD antibody
    • Glutamate receptor 4 antibody
    • Glutamate receptor ionotrophic AMPA 4 antibody
    • Glutamate receptor ionotropic antibody
    • GRIA 4 antibody
    • Gria4 antibody
    • GRIA4_HUMAN antibody
    see all

Images

  • All lanes : Anti-Ionotropic Glutamate receptor 4 (phospho S862) antibody (ab61054) at 1/500 dilution

    Lane 1 : extracts from HepG2 cells treated with Forskolin (40nM, 30mins)
    Lane 2 : extracts from HepG2 cells treated with Forskolin (40nM, 30mins) with immunizing phosphopeptide


    Predicted band size : 102 kDa
    Observed band size : 102 kDa

References

ab61054 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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